| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Nephrology, INC Ignacio Chavez, Mexico City, D.F., Mexico
2 Nephrology, INC Ignacio Chavez, Mexico City, D.F., Mexico; Mexico City, D.F., Mexico
3 Pathology, INC Ignacio Chavez, Mexico City, D.F., Mexico
4 Mexico City, D.F., Mexico; Pathology, INC Ignacio Chavez, Mexico City, D.F., Mexico
5 Nephrology, University of Florida, Gainesville, Florida, United States
6 Tap Pharmaceutical Products, Inc, Lake Forest, Illinois, United States
7 Gainesville, Florida, United States; Nephrology, University of Florida, Gainesville, Florida, United States
* To whom correspondence should be addressed. E-mail: lgsanchezlozada{at}hotmail.com.
Increased fructose consumption is associated with hyperuricemia, metabolic syndrome and renal damage. This study evaluated whether febuxostat (Fx), an investigational non-purine and selective xanthine oxidase inhibitor, could alleviate the features of metabolic syndrome as well as the renal hemodynamic alterations and afferent arteriolopathy induced by a high-fructose diet in rats. Two groups of rats were fed a high-fructose diet (60% fructose) for 8 weeks, and two groups received a normal diet. For each diet, one group was treated with Fx (5-6 mg/kg/day in drinking water) during the last 4 weeks (ie after the onset of metabolic syndrome) and the other received no treatment (placebo, P). Body weight was measured daily. Systolic blood pressure and fasting plasma uric acid (UA), insulin and triglycerides were measured at baseline and at 4 and 8 weeks. Renal hemodynamics and histomorphology were evaluated at the end of the study. A high-fructose diet was associated with hyperuricemia, hypertension as well as increased plasma triglycerides and insulin. Compared to Fructose+P, Fructose+Fx rats showed significantly lowered blood pressure, UA, triglycerides and insulin (p<0.05 for all comparisons). Moreover, Fructose+Fx rats had significantly reduced glomerular pressure, renal vasoconstriction and afferent arteriolar area relative to Fructose+P rats. Fx treatment in rats on a normal diet had no significant effects. In conclusion, normalization of plasma UA with Fx in rats with metabolic syndrome alleviated both metabolic and glomerular hemodynamic and morphologic alterations. These results provide further evidence for a pathogenic role of hyperuricemia in fructose-mediated metabolic syndrome.
This article has been cited by other articles:
|
|
 |
|
  Q.-H. Hu, C. Wang, J.-M. Li, D.-M. Zhang, and L.-D. Kong Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement Am J Physiol Renal Physiol, October 1, 2009; 297(4): F1080 - F1091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-C. SEE, C.-F. KUO, F.-H. CHUANG, H.-Y. LI, Y.-M. CHEN, H.-W. CHEN, and K.-H. YU Serum Uric Acid Is Independently Associated with Metabolic Syndrome in Subjects with and without a Low Estimated Glomerular Filtration Rate J Rheumatol, August 1, 2009; 36(8): 1691 - 1698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. I. Feig, D.-H. Kang, and R. J. Johnson Uric Acid and Cardiovascular Risk N. Engl. J. Med., October 23, 2008; 359(17): 1811 - 1821. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
