AJP - Renal Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol (August 15, 2001). doi:10.1152/ajprenal.0078.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
281/6/F1132    most recent
0078.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kramp, R. A
Right arrow Articles by Caron, N.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Kramp, R. A
Right arrow Articles by Caron, N.

Articles in PresS, published online ahead of print August 15, 2001
Am J Physiol Renal Physiol, 10.1152/ajprenal.0078.2001
Submitted on March 8, 2001
Accepted on July 18, 2001

Endothelin resets renal blood flow autoregulatory efficiency during acute blockade of NO in the rat

Ronald A Kramp1*, Pascale Fourmanoir1, and Nathalie Caron1

1 Physiologie et Pharmacologie, Universite de Mons-Hainaut, Mons, Hainaut, Belgium

* To whom correspondence should be addressed. E-mail: ronald.kramp{at}umh.ac.be.

Renal blood flow (RBF) autoregulatory efficiency may be enhanced during NO inhibition in the rat, as recently reported. Under these conditions, endothelin (ET) synthesis and release may be increased. Our purpose was therefore to determine ET's role in RBF autoregulatory changes induced by NO inhibition. To address this point, ETA/B receptors were blocked in anesthetized rats with bosentan, or selectively with BQ-610 or BQ-788. NO synthesis was inhibited with L-NAME. Mean arterial pressure (MAP) was decreased after bosentan (- 10 mmHg ; P<0.01), or increased after L-NAME (25 mmHg ; P<0.001). RBF measured with an electromagnetic flow probe was reduced by L-NAME (- 50%) and by BQ-788 (- 24%). The pressure limits of the autoregulatory plateau (PA ~100 mmHg) and of no RBF autoregulation (PO ~80 mmHg) were significantly lowered by 15 mmHg after L-NAME but were unchanged after bosentan, BQ-610 or BQ-788. During NO inhibition, autoregulatory resetting was completely hindered by bosentan (PA ~100 mmHg), and by ETB receptor blockade with BQ-788 (PA ~106 mmHg), but not by ETA receptor blockade with BQ-610 (PA ~85 mmHg). These results suggest ET's involvement in the RBF autoregulatory resetting occurring during NO inhibition, possibly by preferential activation of the ETB receptor. The relative contribution of ET's receptor subtypes remains, however, to be further specified.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Lau, I. Sudbury, M. Thomson, P. L. Howard, A. B. Magil, and W. A. Cupples
Salt-resistant blood pressure and salt-sensitive renal autoregulation in chronic streptozotocin diabetes
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2009; 296(6): R1761 - R1770.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
Z. Miloradovic, M. Jerkic, D. Jovovic, N. Mihailovic-Stanojevic, J. G. Milanovic, G. Stosic, and J. Markovic-Lipkovski
Bosentan and losartan ameliorate acute renal failure associated with mild but not strong NO blockade
Nephrol. Dial. Transplant., September 1, 2007; 22(9): 2476 - 2484.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. A. Cupples and B. Braam
Assessment of renal autoregulation
Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1105 - F1123.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Shi, C. Lau, and W. A. Cupples
Interactive modulation of renal myogenic autoregulation by nitric oxide and endothelin acting through ET-B receptors
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R354 - R361.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Shi, X. Wang, K. H. Chon, and W. A. Cupples
Tubuloglomerular feedback-dependent modulation of renal myogenic autoregulation by nitric oxide
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R982 - R991.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Just and W. J. Arendshorst
Nitric oxide blunts myogenic autoregulation in rat renal but not skeletal muscle circulation via tubuloglomerular feedback
J. Physiol., December 15, 2005; 569(3): 959 - 974.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. S. A. Majid, A. Nishiyama, K. E. Jackson, and A. Castillo
Superoxide scavenging attenuates renal responses to ANG II during nitric oxide synthase inhibition in anesthetized dogs
Am J Physiol Renal Physiol, February 1, 2005; 288(2): F412 - F419.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Racasan, J. A. Joles, P. Boer, H. A. Koomans, and B. Braam
NO dependency of RBF and autoregulation in the spontaneously hypertensive rat
Am J Physiol Renal Physiol, July 1, 2003; 285(1): F105 - F112.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.