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Am J Physiol Renal Physiol (August 8, 2001). doi:10.1152/ajprenal.0139.2001
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Articles in PresS, published online ahead of print August 8, 2001
Am J Physiol Renal Physiol, 10.1152/ajprenal.0139.2001
Submitted on May 4, 2001
Accepted on July 27, 2001

Food Restriction Prevents Age-Related Polyuria by a Vasopressin-Dependent Membrane Recruitment of Aquaporin-2

Sophie Combet1, Laurent Teillet2, Ghislaine Geelen3, Benedicte Pitrat1, Renee Gobin1, Soren Nielsen4, Marie-Marcelle Trinh-Trang-Tan1, Bruno Corman1, and Jean-Marc Verbavatz1*

1 DBCM/SBCe, CEA/Saclay, F-91191 Gif-sur-Yvette CEDEX, France
2 Hopital Ste-Perine, AP-HP, F-75781 Paris CEDEX 16, France; DBCM/SBCe, CEA/Saclay, F-91191 Gif-sur-Yvette CEDEX, France
3 UFR Medicale Grange-Blanche, Universite Claude-Bernard, F-69373 Lyon CEDEX 8, France
4 Dept of Cell Biology, University of Aarhus, DK-8000 Aarhus, Denmark

* To whom correspondence should be addressed. E-mail: jmverbavatz{at}cea.fr.

The mechanisms underlying the prevention of age-related polyuria by chronic food restriction were investigated in female WAG/Rij rats. The decreased osmolality of renal papilla observed in senescent rats was not corrected by food restriction. A reduced urea content in the inner medulla of senescent rats, fed ad libitum or food-restricted, was suggested by the marked decrease in expression of UT-A1 and UT-B1 urea transporters. Aquaporin-2 (AQP2) downregulation in the inner medulla of senescent rats was partially prevented by food restriction. Both AQP2 and the phosphorylated form of AQP2 (p-AQP2), whose presence was diffuse within the cytoplasm of collecting duct principal cells in normally fed senescent rats, were preferentially targeted at the apical region of the cells in food-restricted senescent animals. Plasma vasopressin (AVP) was similar in 10- and 30-mo-old rats fed ad libitum, but was doubled in food-restricted 30-mo-old rats. This study indicates (i) that kidney aging is associated with a marked decrease in AQP2, UT-A1, and UT-B1 expression in the inner medulla and a reduced papillary osmolality; (ii) that the prevention of age-related polyuria by chronic food restriction occurs through an improved recruitment of AQP2 and p-AQP2 to the apical membrane in inner medulla principal cells, possibly permitted by increased plasma AVP concentration.




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