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Articles in PresS, published online ahead of print August 30, 2001
Am J Physiol Renal Physiol, 10.1152/ajprenal.0197.2001
Submitted on June 27, 2001
Accepted on August 13, 2001
1 Renal Service and Laboratory, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomedicas (INBIOMED), Maracaibo, Zulia, Venezuela
2 Nephrology, Instituto de Cardiologia, Mexico, D.F, Mexico
3 Renal Division, Baylor Medical College, Houston, Texas, USA
* To whom correspondence should be addressed. E-mail: bri{at}iamnet.com.
Immunocompetent cells infiltrate the kidney in several models of experimental hypertension. We have previously shown that reduction of this infiltrate results in prevention of salt-sensitive hypertension induced by short-term angiotensin II infusion and nitric oxide inhibition. We therefore studied if hypertension could be controlled in genetically hypertensive rats (SHR) by the administration of 20 mg/kg/day of the immunosuppressive drug mycophenolate mofetil (MMF group n=35). Other SHR received vehicle (=35) and Wistar Kyoto rats (n=20) were used as controls. MMF or vehicle were given in two separate 4-week periods separated by a 3-week interval. Systemic hypertension was reduced to normal levels in both periods of MMF treatment in association with a reduction of lymphocyte, macrophage and angiotensin II positive cells infiltrating the kidney. Oxidative stress was also reduced by MMF, as indicated by a reduction in urinary MDA, renal MDA content and superoxide positive cells and it was highly correlated with blood pressure levels. We conclude that the renal immune infiltrate plays a major role in the hypertension of the SHR.
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