AJP - Renal Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 280: F675-F682, 2001;
0363-6127/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (94)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Loffing, J.
Right arrow Articles by Verrey, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Loffing, J.
Right arrow Articles by Verrey, F.
Vol. 280, Issue 4, F675-F682, April 2001

Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK

Johannes Loffing2,*, Marija Zecevic1,*, Eric Féraille3, Brigitte Kaissling2, Carol Asher4, Bernard C. Rossier5, Gary L. Firestone6, David Pearce7, and François Verrey1

1 Institute of Physiology and 2 Institute of Anatomy, University of Zürich, CH-8057 Zürich; 3 Division de Néphrologie, Hôpital Cantonal Universitaire, CH-1211 Geneva; 4 Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel; 5 Institut de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland; 6 Department of Molecular and Cell Biology and The Cancer Research Laboratory, University of Califonia, Berkeley 94720; and 7 Division of Nephrology, Department of Medicine and Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143

Aldosterone controls sodium reabsorption and potassium secretion in the aldosterone-sensitive distal nephron (ASDN). Although clearance measurements have shown that aldosterone induces these transports within 30-60 min, no early effects have been demonstrated in vivo at the level of the apical epithelial sodium channel (ENaC), the main effector of this regulation. Here we show by real-time RT-PCR and immunofluorescence that an aldosterone injection in adrenalectomized rats induces alpha -ENaC subunit expression along the entire ASDN within 2 h, whereas beta - and gamma -ENaC are constitutively expressed. In the proximal ASDN portions only, ENaC is shifted toward the apical cellular pole and the apical plasma membrane within 2 and 4 h, respectively. To address the question of whether the early aldosterone-induced serum and glucocorticoid-regulated kinase (SGK) might mediate this apical shift of ENaC, we analyzed SGK induction in vivo. Two hours after aldosterone, SGK was highly induced in all segment-specific cells of the ASDN, and its level decreased thereafter. In Xenopus laevis oocytes, SGK induced ENaC activation and surface expression by a kinase activity-dependent mechanism. In conclusion, the rapid in vivo accumulation of SGK and alpha -ENaC after aldosterone injection takes place along the entire ASDN, whereas the translocation of alpha ,beta ,gamma -ENaC to the apical plasma membrane is restricted to its proximal portions. Results from oocyte experiments suggest the hypothesis that a localized activation of SGK may play a role in the mediation of ENaC translocation.

Xenopus laevis oocytes; sodium transport; kidney; collecting duct; epithelial sodium channel; serum and glucocorticoid-regulated kinase

* J. Loffing and M. Zecevic contributed equally to this work.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Fejes-Toth, G. Frindt, A. Naray-Fejes-Toth, and L. G. Palmer
Epithelial Na+ channel activation and processing in mice lacking SGK1
Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1298 - F1305.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
G. Frindt, Z. Ergonul, and L. G. Palmer
Surface Expression of Epithelial Na Channel Protein in Rat Kidney
J. Gen. Physiol., May 26, 2008; 131(6): 617 - 627.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. S. Raikwar and C. P. Thomas
Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel
Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1157 - F1165.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Taruno, N. Niisato, and Y. Marunaka
Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F177 - F186.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Li, C. S. Wingo, and S.-L. Xia
Downregulation of SGK1 by nucleotides in renal tubular epithelial cells
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1751 - F1757.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. P. Hughey and T. R. Kleyman
Functional cross talk between ENaC and pendrin
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1439 - F1440.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. A. Martel, D. Michael, G. Fejes-Toth, and A. Naray-Fejes-Toth
Melanophilin, a novel aldosterone-induced gene in mouse cortical collecting duct cells
Am J Physiol Renal Physiol, September 1, 2007; 293(3): F904 - F913.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Li, W. Wang, R. Norregaard, M. A. Knepper, S. Nielsen, and J. Frokiaer
Altered expression of epithelial sodium channel in rats with bilateral or unilateral ureteral obstruction
Am J Physiol Renal Physiol, July 1, 2007; 293(1): F333 - F341.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. Cordas, A. Naray-Fejes-Toth, and G. Fejes-Toth
Subcellular location of serum- and glucocorticoid-induced kinase-1 in renal and mammary epithelial cells
Am J Physiol Cell Physiol, May 1, 2007; 292(5): C1971 - C1981.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
P. Fakitsas, G. Adam, D. Daidie, M. X. van Bemmelen, F. Fouladkou, A. Patrignani, U. Wagner, R. Warth, S. M.R. Camargo, O. Staub, et al.
Early Aldosterone-Induced Gene Product Regulates the Epithelial Sodium Channel by Deubiquitylation
J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1084 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
C.-T. Chang, M.-S. Wu, Y.-C. Tian, K.-H. Chen, C.-C. Yu, C.-H. Liao, C.-C. Hung, and C.-W. Yang
Enhancement of epithelial sodium channel expression in renal cortical collecting ducts cells by advanced glycation end products
Nephrol. Dial. Transplant., March 1, 2007; 22(3): 722 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. G. Fuster, I. A. Bobulescu, J. Zhang, J. Wade, and O. W. Moe
Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin
Am J Physiol Renal Physiol, February 1, 2007; 292(2): F577 - F585.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. C. Thiesson, B. L. Jensen, C. Bistrup, P. D. Ottosen, A. D. McNeilly, R. Andrew, J. Seckl, and O. Skott
Renal sodium retention in cirrhotic rats depends on glucocorticoid-mediated activation of mineralocorticoid receptor due to decreased renal 11beta-HSD-2 activity
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R625 - R636.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Nielsen, T.-H. Kwon, J. Frokiaer, M. A. Knepper, and S. Nielsen
Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade
Am J Physiol Renal Physiol, January 1, 2007; 292(1): F382 - F394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Y. Huang, K. M. Boini, H. Osswald, B. Friedrich, F. Artunc, S. Ullrich, J. Rajamanickam, M. Palmada, P. Wulff, D. Kuhl, et al.
Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1264 - F1273.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. Lang, C. Bohmer, M. Palmada, G. Seebohm, N. Strutz-Seebohm, and V. Vallon
(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms.
Physiol Rev, October 1, 2006; 86(4): 1151 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Bhalla, R. Soundararajan, A. C. Pao, H. Li, and D. Pearce
Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ
Am J Physiol Renal Physiol, October 1, 2006; 291(4): F714 - F721.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Z. Ergonul, G. Frindt, and L. G. Palmer
Regulation of maturation and processing of ENaC subunits in the rat kidney
Am J Physiol Renal Physiol, September 1, 2006; 291(3): F683 - F693.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. M. Boini, A. M. Hennige, D. Y. Huang, B. Friedrich, M. Palmada, C. Boehmer, F. Grahammer, F. Artunc, S. Ullrich, D. Avram, et al.
Serum- and glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance.
Diabetes, July 1, 2006; 55(7): 2059 - 2066.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
F. Grahammer, G. Henke, C. Sandu, R. Rexhepaj, A. Hussain, B. Friedrich, T. Risler, M. Metzger, L. Just, T. Skutella, et al.
Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1
Am J Physiol Gastrointest Liver Physiol, June 1, 2006; 290(6): G1114 - G1123.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Nielsen, T.-H. Kwon, J. Frokiaer, M. A. Knepper, and S. Nielsen
Lithium-induced NDI in rats is associated with loss of {alpha}-ENaC regulation by aldosterone in CCD
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1222 - F1233.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. Grahammer, F. Artunc, D. Sandulache, R. Rexhepaj, B. Friedrich, T. Risler, J. A. McCormick, K. Dawson, J. Wang, D. Pearce, et al.
Renal function of gene-targeted mice lacking both SGK1 and SGK3
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R945 - R950.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Y. Huang, K. M. Boini, B. Friedrich, M. Metzger, L. Just, H. Osswald, P. Wulff, D. Kuhl, V. Vallon, and F. Lang
Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R935 - R944.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
W. Zhang, X. Xia, D. I. Jalal, T. Kuncewicz, W. Xu, G. D. Lesage, and B. C. Kone
Aldosterone-sensitive repression of ENaC{alpha} transcription by a histone H3 lysine-79 methyltransferase
Am J Physiol Cell Physiol, March 1, 2006; 290(3): C936 - C946.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. W. Kim, S. de Seigneux, M. C. Sassen, J. Lee, J. Kim, M. A. Knepper, J. Frokiaer, and S. Nielsen
Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats
Am J Physiol Renal Physiol, March 1, 2006; 290(3): F674 - F687.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
O. Helve, S. Andersson, T. Kirjavainen, and O. M. Pitkanen
Improvement of Lung Compliance during Postnatal Adaptation Correlates with Airway Sodium Transport
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 448 - 452.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Wang, C. Li, L. N. Nejsum, H. Li, S. W. Kim, T.-H. Kwon, T. E. N. Jonassen, M. A. Knepper, K. Thomsen, J. Frokiaer, et al.
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Am J Physiol Renal Physiol, February 1, 2006; 290(2): F530 - F541.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Shimizu, T. Yoshida, M. Wakamori, M. Ishii, T. Okada, M. Takahashi, M. Seto, K. Sakurada, Y. Kiuchi, and Y. Mori
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells
J. Physiol., January 15, 2006; 570(2): 219 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Makhanova, G. Lee, N. Takahashi, M. L. Sequeira Lopez, R. A. Gomez, H.-S. Kim, and O. Smithies
Kidney function in mice lacking aldosterone
Am J Physiol Renal Physiol, January 1, 2006; 290(1): F61 - F69.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Lourdel, J. Loffing, G. Favre, M. Paulais, A. Nissant, P. Fakitsas, C. Creminon, E. Feraille, F. Verrey, J. Teulon, et al.
Hyperaldosteronemia and Activation of the Epithelial Sodium Channel Are Not Required for Sodium Retention in Puromycin-Induced Nephrosis
J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3642 - 3650.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Loffing and L. Schild
Functional Domains of the Epithelial Sodium Channel
J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3175 - 3181.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
Z. Yu, A. Serra, D. Sauter, J. Loffing, D. Ackermann, F. J. Frey, B. M. Frey, and B. Vogt
Sodium retention in rats with liver cirrhosis is associated with increased renal abundance of NaCl cotransporter (NCC)
Nephrol. Dial. Transplant., September 1, 2005; 20(9): 1833 - 1841.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
J. A. McCormick, V. Bhalla, A. C. Pao, and D. Pearce
SGK1: A Rapid Aldosterone-Induced Regulator of Renal Sodium Reabsorption
Physiology, April 1, 2005; 20(2): 134 - 139.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
I. E. Veizis and C. U. Cotton
Abnormal EGF-dependent regulation of sodium absorption in ARPKD collecting duct cells
Am J Physiol Renal Physiol, March 1, 2005; 288(3): F474 - F482.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Boyd and A. Naray-Fejes-Toth
Gene regulation of ENaC subunits by serum- and glucocorticoid-inducible kinase-1
Am J Physiol Renal Physiol, March 1, 2005; 288(3): F505 - F512.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
M. Keller-Wood, C. E. Wood, Y. Hua, and D. Zhang
Mineralocorticoid Receptor Expression in Late-Gestation Ovine Fetal Lung
Reproductive Sciences, February 1, 2005; 12(2): 84 - 91.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Vallon, P. Wulff, D. Y. Huang, J. Loffing, H. Volkl, D. Kuhl, and F. Lang
Role of Sgk1 in salt and potassium homeostasis
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R4 - R10.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Lang
Surfing the lipid bilayer: how basolateral insulin receptors regulate Na+ channels in the apical cell membrane. Focus on "Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na+ channels"
Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1539 - C1540.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Frindt and L. G. Palmer
Apical potassium channels in the rat connecting tubule
Am J Physiol Renal Physiol, November 1, 2004; 287(5): F1030 - F1037.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. Meneton, J. Loffing, and D. G. Warnock
Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule
Am J Physiol Renal Physiol, October 1, 2004; 287(4): F593 - F601.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. P. Thomas, J. R. Campbell, P. J. Wright, and R. F. Husted
cAMP-stimulated Na+ transport in H441 distal lung epithelial cells: role of PKA, phosphatidylinositol 3-kinase, and sgk1
Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L843 - L851.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Loffing, V. Vallon, D. Loffing-Cueni, F. Aregger, K. Richter, L. Pietri, M. Bloch-Faure, J. G.J. Hoenderop, G. E. Shull, P. Meneton, et al.
Altered Renal Distal Tubule Structure and Renal Na+ and Ca2+ Handling in a Mouse Model for Gitelman's Syndrome
J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2276 - 2288.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
F. Fouladkou, R. Alikhani-Koopaei, B. Vogt, S. Y. Flores, L. Malbert-Colas, M.-C. Lecomte, J. Loffing, F. J. Frey, B. M. Frey, and O. Staub
A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes
Am J Physiol Renal Physiol, September 1, 2004; 287(3): F550 - F561.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. H. Dave, N. Schulz, M. Zecevic, C. A. Wagner, and F. Verrey
Expression of heteromeric amino acid transporters along the murine intestine
J. Physiol., July 15, 2004; 558(2): 597 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. W. Kim, W. Wang, J. Nielsen, J. Praetorius, T.-H. Kwon, M. A. Knepper, J. Frokiaer, and S. Nielsen
Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats
Am J Physiol Renal Physiol, May 1, 2004; 286(5): F922 - F935.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
D. Y. Huang, P. Wulff, H. Volkl, J. Loffing, K. Richter, D. Kuhl, F. Lang, and V. Vallon
Impaired Regulation of Renal K+ Elimination in the sgk1-Knockout Mouse
J. Am. Soc. Nephrol., April 1, 2004; 15(4): 885 - 891.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
T. Coric, N. Hernandez, D. A. de la Rosa, D. Shao, T. Wang, and C. M. Canessa
Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium
Am J Physiol Gastrointest Liver Physiol, April 1, 2004; 286(4): G663 - G670.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Frindt and L. G. Palmer
Na channels in the rat connecting tubule
Am J Physiol Renal Physiol, April 1, 2004; 286(4): F669 - F674.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. Summa, S. M. R. Camargo, C. Bauch, M. Zecevic, and F. Verrey
Isoform specificity of human Na+,K+-ATPase localization and aldosterone regulation in mouse kidney cells
J. Physiol., March 1, 2004; 555(2): 355 - 364.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
B. C. Rossier
The Epithelial Sodium Channel: Activation by Membrane-Bound Serine Proteases
Proceedings of the ATS, January 1, 2004; 1(1): 4 - 9.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Nielsen, T.-H. Kwon, J. Praetorius, Y.-H. Kim, J. Frokiaer, M. A. Knepper, and S. Nielsen
Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI
Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1198 - F1209.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Renal Physiol.Home page
O. A. Weisz and J. P. Johnson
Noncoordinate regulation of ENaC: paradigm lost?
Am J Physiol Renal Physiol, November 1, 2003; 285(5): F833 - F842.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. L. Gumz, M. P. Popp, C. S. Wingo, and B. D. Cain
Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line
Am J Physiol Renal Physiol, October 1, 2003; 285(4): F664 - F673.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Auberson, N. Hoffmann-Pochon, A. Vandewalle, S. Kellenberger, and L. Schild
Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin
Am J Physiol Renal Physiol, September 1, 2003; 285(3): F459 - F471.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Lebowitz, B. An, R. S. Edinger, M. L. Zeidel, and J. P. Johnson
Effect of altered Na+ entry on expression of apical and basolateral transport proteins in A6 epithelia
Am J Physiol Renal Physiol, September 1, 2003; 285(3): F524 - F531.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
O. G. Muller, R. G. Parnova, G. Centeno, B. C. Rossier, D. Firsov, and J.-D. Horisberger
Mineralocorticoid Effects in the Kidney: Correlation between {alpha}ENaC, GILZ, and Sgk-1 mRNA Expression and Urinary Excretion of Na+ and K+
J. Am. Soc. Nephrol., May 1, 2003; 14(5): 1107 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
M. Takada and M. Kasai
Prolactin increases open-channel density of epithelial Na+ channel in adult frog skin
J. Exp. Biol., April 15, 2003; 206(8): 1319 - 1323.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
M. A. KNEPPER, G.-H. KIM, and S. MASILAMANI
Renal Tubule Sodium Transporter Abundance