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Am J Physiol Renal Physiol 284: F1164-F1170, 2003. First published March 11, 2003; doi:10.1152/ajprenal.00441.2002
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Vol. 284, Issue 6, F1164-F1170, June 2003

Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract

Osamu Saito1, Youfei Guan1, Zhonghua Qi1, Linda S. Davis1, Martin Kömhoff2, Yukihiko Sugimoto3, Shuh Narumiya3, Richard M. Breyer1, and Matthew D. Breyer1

1 Division of Nephrology, Department of Medicine, Vanderbilt University Veterans Affairs Medical Center, Nashville, Tennessee 37212; and Departments of 3 Pharmacology, Faculty of Medicine, and 2 Physiological Chemistry and Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan 606

PGF2alpha is one of the major prostanoids produced by the kidney. The cellular effects of PGF2alpha are mediated by a G protein-coupled transmembrane receptor designated the FP receptor. Both in situ hybridization and beta -galactosidase knocked into the endogenous FP locus were used to determine the cellular distribution of the mouse FP receptor. Specific labeling was detected in the kidney, ovary, and uterus. Abundant FP expression in ovarian follicles and uterus is consistent with previous reports of failed parturition in FP-/- mice. In the kidney, coexpression of the mFP mRNA with the thiazide-sensitive cotransporter defined its expression in the distal convoluted tubule (DCT). FP receptor was also present in aquaporin-2-positive cortical collecting ducts (CCD). No FP mRNA was detected in glomeruli, proximal tubules, or thick ascending limbs. Intrarenal expression of the FP receptor in the DCT and CCD suggests an important role for the FP receptor regulating water and solute transport in these segments of the nephron.

dinoprost; nephron; natriuresis; water


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