AJP - Renal Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 288: F637-F641, 2005. First published November 30, 2004; doi:10.1152/ajprenal.00140.2004
0363-6127/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
288/4/F637    most recent
00140.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Katz-Brull, R.
Right arrow Articles by Lenkinski, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Katz-Brull, R.
Right arrow Articles by Lenkinski, R. E.

TRANSLATIONAL PHYSIOLOGY

Decreases in free cholesterol and fatty acid unsaturation in renal cell carcinoma demonstrated by breath-hold magnetic resonance spectroscopy

Rachel Katz-Brull,1 Neil M. Rofsky,1 Martina M. Morrin,1 Ivan Pedrosa,1 Daniel J. George,2 M. Dror Michaelson,3 Robert P. Marquis,1 Michal Maril,1 Carolina Noguera,1 and Robert E. Lenkinski1

1Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School; 2Dana-Farber Cancer Institute, Harvard Medical School; and 3Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

Submitted 19 April 2004 ; accepted in final form 19 November 2004

Increased utilization of cross-sectional imaging has resulted in increased detection of incidental renal tumors. The noninvasive characterization of renal tissue has important implications for the diagnosis of renal malignancies and treatment monitoring. Recently, multiple breath-hold averaged proton magnetic resonance spectroscopy (1H-MRS) performed at high field has enabled the use of this noninvasive metabolic profiling technique for the investigation of the abdomen. Multiple breath-hold averaged 1H-MRS at high field (3T) was obtained in the kidneys of 10 healthy volunteers and in renal cell carcinoma tumors of 14 patients. The spectra of normal kidneys showed four main groups of resonances: 1) at 5.4–5.6 ppm, attributed to C6 of cholesterol and the unsaturated parts of the olefinic region of fatty acids; 2) at 4.7 ppm, attributed to the residual water signal; 3) at 3.2 ppm, attributed to trimethylamine moiety of choline metabolites; and 4) at 1.3 and 0.9 ppm, attributed to the methylenes and terminal methyls of lipids. The ratio of the signal at 5.4 ppm to that of 1.3 ppm was 19-fold lower in renal cell carcinomas than in healthy kidneys, tied P = 0.0003 Mann-Whitney U-test, suggesting a decrease in both free cholesterol and the degree of unsaturation of fatty acids in the malignant tissue. This metabolic shift is in agreement with previous ex vivo studies of human renal cell carcinoma. The ability to detect renal metabolic shifts noninvasively may improve the specificity of preoperative renal tissue characterization and may provide a new modality for treatment monitoring.

clinical study; proton magnetic resonance spectroscopy; 3T


Address for reprint requests and other correspondence: R. E. Lenkinski, Dept. of Radiology, Beth Israel Deaconess Medical Ctr., 330 Brookline Ave., Boston, MA 02215 (E-mail: rlenkins{at}bidmc.harvard.edu)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.