AJP - Renal AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 288: F912-F920, 2005. First published January 4, 2005; doi:10.1152/ajprenal.00432.2004
0363-6127/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
288/5/F912    most recent
00432.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ge, Y.
Right arrow Articles by Kohan, D. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ge, Y.
Right arrow Articles by Kohan, D. E.

Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality

Yuqiang Ge,1 Dowahn Ahn,2 Peter K. Stricklett,1 Alisa K. Hughes,1 Masashi Yanagisawa,3 Joseph G. Verbalis,4 and Donald E. Kohan1,5

1Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, Utah; 2Department of Physiology, Kosin University College of Medicine, Kosin, South Korea; 3Howard Hughes Medical Institute, University of Texas Southwestern, Dallas, Texas; 4Division of Endocrinology and Metabolism, Georgetown University, Washington, District of Columbia; and 5Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah

Submitted 3 December 2004 ; accepted in final form 28 December 2004

In vitro studies suggest that endothelin-1 (ET-1) inhibits vasopressin (AVP)-stimulated water permeability in the collecting duct (CD). To evaluate the role of CD-derived ET-1 in regulating renal water metabolism, the ET-1 gene was selectively disrupted in the CD (CD ET-1 KO). During normal water intake, urinary osmolality (Uosm), plasma Na concentration, urine volume, and renal aquaporin-2 (AQP2) levels were unchanged, but plasma AVP concentration was reduced in CD ET-1 KO animals. CD ET-1 KO mice had impaired ability to excrete an acute, but not a chronic, water load, and this was associated with increased CD ET-1 mRNA in control, but not CD ET-1 KO, mice. In response to continuous infusion of 1-desamino-8-D-arginine vasopressin, CD ET-1 KO mice had greater increases in Uosm, V2 and AQP2 mRNA, and phosphorylation of AQP2. CD suspensions from CD ET-1 KO mice had enhanced AVP- and forskolin-stimulated cAMP accumulation. These data indicate that CD ET-1 KO increases renal sensitivity to the urinary concentrating effects of AVP and suggest that ET-1 functions as a physiological autocrine regulator of AVP action in the CD.

aquaporin-2; adenosine 3',5'-cyclic monophosphate; inner medullary collecting duct


Address for reprint requests and other correspondence: D. E. Kohan, Division of Nephrology, Univ. of Utah Health Sciences Center, 30 North 1900 East, Salt Lake City, UT 84132 (E-mail: donald.kohan{at}hsc.utah.edu)




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
L. R. Stow, M. L. Gumz, I. J. Lynch, M. M. Greenlee, A. Rudin, B. D. Cain, and C. S. Wingo
Aldosterone Modulates Steroid Receptor Binding to the Endothelin-1 Gene (edn1)
J. Biol. Chem., October 30, 2009; 284(44): 30087 - 30096.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Soodvilai, Z. Jia, M.-H. Wang, Z. Dong, and T. Yang
mPGES-1 deletion impairs diuretic response to acute water loading
Am J Physiol Renal Physiol, May 1, 2009; 296(5): F1129 - F1135.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Rieg and V. Vallon
ATP and adenosine in the local regulation of water transport and homeostasis by the kidney
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R419 - R427.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Zhang, J. M. Sands, D. E. Kohan, R. D. Nelson, C. F. Martin, N. G. Carlson, C. D. Kamerath, Y. Ge, J. D. Klein, and B. K. Kishore
Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice
Am J Physiol Renal Physiol, December 1, 2008; 295(6): F1715 - F1724.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Rieg, K. Pothula, J. Schroth, J. Satriano, H. Osswald, J. Schnermann, P. A. Insel, R. A. Bundey, and V. Vallon
Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors
Am J Physiol Renal Physiol, March 1, 2008; 294(3): F638 - F644.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Vallon
P2 receptors in the regulation of renal transport mechanisms
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F10 - F27.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Ge, K. A. Strait, P. K. Stricklett, T. Yang, and D. E. Kohan
Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion
Am J Physiol Renal Physiol, December 1, 2007; 293(6): F1805 - F1810.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. A. Fenton and M. A. Knepper
Mouse Models and the Urinary Concentrating Mechanism in the New Millennium
Physiol Rev, October 1, 2007; 87(4): 1083 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. K. Ahrabi, S. Terryn, G. Valenti, N. Caron, C. Serradeil-Le Gal, D. Raufaste, S. Nielsen, S. Horie, J.-M. Verbavatz, and O. Devuyst
PKD1 Haploinsufficiency Causes a Syndrome of Inappropriate Antidiuresis in Mice
J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1740 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. Ronzaud, J. Loffing, M. Bleich, N. Gretz, H.-J. Grone, G. Schutz, and S. Berger
Impairment of Sodium Balance in Mice Deficient in Renal Principal Cell Mineralocorticoid Receptor
J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1679 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M.-Y. Chang, E. Parker, M. El Nahas, J. L. Haylor, and A. C.M. Ong
Endothelin B Receptor Blockade Accelerates Disease Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease
J. Am. Soc. Nephrol., February 1, 2007; 18(2): 560 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Ge, A. Bagnall, P. K. Stricklett, K. Strait, D. J. Webb, Y. Kotelevtsev, and D. E. Kohan
Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1274 - F1280.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. K. Stricklett, A. K. Hughes, and D. E. Kohan
Endothelin-1 stimulates NO production and inhibits cAMP accumulation in rat inner medullary collecting duct through independent pathways
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1315 - F1319.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
N. Dhaun, J. Goddard, and DavidJ. Webb
The Endothelin System and Its Antagonism in Chronic Kidney Disease
J. Am. Soc. Nephrol., April 1, 2006; 17(4): 943 - 955.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Ge, P. K. Stricklett, A. K. Hughes, M. Yanagisawa, and D. E. Kohan
Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure
Am J Physiol Renal Physiol, October 1, 2005; 289(4): F692 - F698.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. L. Garvin and M. Herrera
Physiological actions of renal collecting duct endothelin
Am J Physiol Renal Physiol, May 1, 2005; 288(5): F910 - F911.
[Full Text] [PDF]

Home page
 PhysiologyHome page
Highlights from the Literature
Physiology, April 1, 2005; 20(2): 81 - 85.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.