HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 292/5/F1548    most recent 00347.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (23) Citing Articles via Google Scholar Google Scholar Articles by Lee, V. S. Articles by Leonard, E. F. Search for Related Content PubMed PubMed Citation Articles by Lee, V. S. Articles by Leonard, E. F.

Renal function measurements from MR renography and a simplified multicompartmental model

¹Department of Radiology, New York University School of Medicine, Departments of ³Biomedical Engineering and ⁴Chemical Engineering, Columbia University, New York, New York; and ²Siemens Medical Solutions, Malvern, Pennsylvania

Submitted 31 August 2006 ; accepted in final form 1 January 2007

The purpose of this study was to determine the accuracy and sources of error in estimating single-kidney glomerular filtration rate (GFR) derived from low-dose gadolinium-enhanced T1-weighted MR renography. To analyze imaging data, MR signal intensity curves were converted to concentration vs. time curves, and a three-compartment, six-parameter model of the vascular-nephron system was used to analyze measured aortic, cortical, and medullary enhancement curves. Reliability of the parameter estimates was evaluated by sensitivity analysis and by Monte Carlo analyses of model solutions to which random noise had been added. The dominant sensitivity of the medullary enhancement curve to GFR 1–4 min after tracer injection was supported by a low coefficient of variation in model-fit GFR values (4%) when measured data were subjected to 5% noise. These analyses also showed the minimal effects of bolus dispersion in the aorta on parameter reliability. Single-kidney GFR from MR renography analyzed by the three-compartment model (4.0–71.4 ml/min) agreed well with reference measurements from ^99mTc-DTPA clearance and scintigraphy (r = 0.84, P < 0.001). Bland-Altman analysis showed an average difference of 11.9 ml/min (95% confidence interval = 5.8–17.9 ml/min) between model and reference values. We conclude that a nephron-based multicompartmental model can be used to derive clinically useful estimates of single-kidney GFR from low-dose MR renography.

multicompartmental modeling; magnetic resonance imaging; tracer kinetics; glomerular filtration rate; radionuclide scintigraphy; gadolinium chelates

This article has been cited by other articles:

				H. Chandarana and V. S. Lee Renal Functional MRI: Are We Ready for Clinical Application? Am. J. Roentgenol., June 1, 2009; 192(6): 1550 - 1557. [Abstract] [Full Text] [PDF]

				J. L. Zhang, H. Rusinek, L. Bokacheva, R. P. Lim, Q. Chen, P. Storey, K. Prince, E. M. Hecht, D. C. Kim, and V. S. Lee Angiotensin-converting enzyme inhibitor-enhanced MR renography: repeated measures of GFR and RPF in hypertensive patients Am J Physiol Renal Physiol, April 1, 2009; 296(4): F884 - F891. [Abstract] [Full Text] [PDF]