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Am J Physiol Renal Physiol 293: F1761-F1765, 2007. First published October 10, 2007; doi:10.1152/ajprenal.00400.2007
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INVITED REVIEW

Complex roles of PIP2 in the regulation of ion channels and transporters

Chou-Long Huang

Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

Submitted 29 August 2007 ; accepted in final form 3 October 2007

The regulation of ion channels and transporters by phosphoinositides has received much attention over the past 10 years. There are multiple potential mechanisms for regulation of ion channels and transporters by PIP2, including a direct binding of PIP2 to the target proteins, alterations of membrane insertion, and retrieval. Added to the complexities of multiple potential mechanisms is how cells use PIP2 to regulate so many different processes. Here, I briefly review several past and recent studies to illustrate the complexities and raise outstanding questions for future studies.

endocytosis; exocytosis; phosphoinositide; PIP5K; Arf; Rho


Address for reprint requests and other correspondence: C.-L. Huang, UT Southwestern Medical Center, Dept. of Medicine, 5323 Harry Hines Blvd., Dallas, TX 75390-8856 (e-mail: chou-long.huang{at}utsouthwestern.edu)




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