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Am J Physiol Renal Physiol (May 14, 2008). doi:10.1152/ajprenal.90264.2008
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Submitted on April 21, 2008
Revised on May 12, 2008
Accepted on May 13, 2008

Biology of Claudins

Susanne Angelow1, Robert Ahlstrom1, and Alan S. L. Yu1*

1 University of Southern California Keck School of Medicine

* To whom correspondence should be addressed. E-mail: alanyu{at}usc.edu.

Claudins are a family of tight junction membrane proteins that regulate paracellular permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are expressed throughout the renal tubule and mutations in 2 claudin genes are now known to cause familial hypercalciuric hypomagnesemia with nephrocalcinosis. In this review, we discuss recent advances in our understanding of the physiologic role of various claudins in normal kidney function, and in understanding the fundamental biology of claudins, including the molecular basis for selectivity of permeation, claudin interactions in tight junction formation, and regulation of claudins by protein kinases and other intracellular signals.




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