Serum amyloid A protein (SAA), a prominent component of the acute phase response, is strongly expressed in developing and repairing kidneys and promotes tubulogenesis. Accordingly, we reprogrammed relatively undifferentiated NRK52E cells with the mouse SAA1.1 gene and transplanted SAA positive and negative cells into rats with acute renal failure. We found that SAA positive cells accelerated renal recovery in three models of acute renal failure, gentamicin nephrotoxicity, cisplatin-mediated renal injury, and ischemia/reperfusion renal injury. The dramatic improvement of renal failure was demonstrable within 2 days consistent with an early paracrine effect. However, abundant donor cells were also found integrated in the healing tubular architecture after 7 days. We conclude that infusions of SAA positive cells promote renal recovery after acute renal failure and offer a potentially powerful and novel therapy of renal failure.
- Acute-phase response
- acute renal failure
- Copyright © 2010, American Journal of Physiology - Renal Physiology