The (pro)renin receptor (PRR) is a multifunctional protein that is part of the renin angiotensin system and is an important accessory molecule for the vacuolar H+-ATPase. The PRR is widely expressed in the kidney with relatively high abundance in the distal nephron. Determining the physiological relevance of the PRR has been challenging due to early lethality in whole animal and cell-specific PRR knockout models. Recently, viable renal cell-specific PRR knockout mice have been developed; these studies suggest that PRR in the nephron can modulate renal function via angiotensin-II (Ang-II) dependent and independent cell signaling pathways. In this mini-review, we highlight new developments in understanding nephron PRR function in health and in pathophysiological conditions.
- prorenin receptor
- renal function
- blood pressure
- water transport
- Copyright © 2016, American Journal of Physiology-Renal Physiology