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Cover Caption:
Cover: Immunolocalization of antibody to
urea transporter in section of rat kidney demonstrates the specialized
location of the UT-A2 isoform (green) in different regions of
descending thin limb of the loop of Henle. Vascular elements are
labeled by anti-von Willebrand factor (vWF; blue); other structures are
labeled by anti-aquaporin-1 (AQP1; red). Descending vasa recta (pink)
have both vWF and AQP1. Upper region of descending thin limbs of
short-looped nephrons lacks UT-A labeling but shows AQP1 labeling. Thin
limbs close to inner medulla label with anti-UT-A but lack anti-AQP1 label. See related article by J. B. Wade, A. J. Lee, J. Liu, C. A. Ecelbarger, C. Mitchell, A. D. Bradford, J. Terris, G.-H. Kim, and M. A. Knepper. UT-A2: a 55-kDa urea transporter in thin descending limb
whose abundance is regulated by vasopressin. Am. J. Physiol. Renal
Physiol. 278:F52-F62, 2000.
Copyright © 2003 by the American Physiological Society.