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![]() [Cover Caption] Other Issues: |
Contents: Volume 284, Issue 3
March 2003 [Index by Author] [Editorial Board]
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Cover: Mouse bladder urothelium is covered by terminally differentiated "umbrella" cells. The apical surface of these umbrella cells is made of numerous urothelial plaques up to 1 µm in diameter, consisting of hexagonally packed two-dimensional crystals of 16-nm uroplakin particles, which contribute to the permeability function of urothelium. The sample was processed by the quick-freeze, deep-etch technique and visualized by scanning electron microscopy. See related article by Hu P, Meyers S, Liang F-X, Deng F-M, Kachar B, Zeidel ML, and Sun T-T. Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability. Am J Physiol Renal Physiol 283: F1200-F1207, 2002.
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