EDITORIAL FOCUS:

Dragos Olteanu, Michael B. Hovater, and Erik M. Schwiebert

Intraluminal autocrine purinergic signaling within cysts: implications for the progression of diseases that involve encapsulated cyst formation
Am J Physiol Renal Physiol 292: F11-F14, 2007. First published August 29, 2006; doi:10.1152/ajprenal.00291.2006 [Full Text] [PDF]  

Clare M. Turner, Brian F. King, Kaila S. Srai, and Robert J. Unwin

Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro
Am J Physiol Renal Physiol 292: F15-F25, 2007. First published July 18, 2006; doi:10.1152/ajprenal.00103.2006 [Abstract] [Full Text] [PDF]  

Edwin K. Jackson

Confirmation of the pivotal role of Gs in renin release
Am J Physiol Renal Physiol 292: F26-F26, 2007. First published July 11, 2006; doi:10.1152/ajprenal.00242.2006 [Full Text] [PDF]  

Limeng Chen, Soo Mi Kim, Mona Oppermann, Robert Faulhaber-Walter, Yuning Huang, Diane Mizel, Min Chen, Maria Luisa Sequeira Lopez, Lee S. Weinstein, R. Ariel Gomez, Josie P. Briggs, and Jurgen Schnermann

Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gs in juxtaglomerular cells
Am J Physiol Renal Physiol 292: F27-F37, 2007. First published July 5, 2006; doi:10.1152/ajprenal.00193.2006 [Abstract] [Full Text] [PDF]  

TRANSLATIONAL PHYSIOLOGY:

Michaela Endemann, Helga Bergmeister, Bettina Bidmon, Michael Boehm, Dagmar Csaicsich, Laura Malaga-Dieguez, Klaus Arbeiter, Heinz Regele, Kurt Herkner, and Christoph Aufricht

Evidence for HSP-mediated cytoskeletal stabilization in mesothelial cells during acute experimental peritoneal dialysis
Am J Physiol Renal Physiol 292: F47-F56, 2007; doi:10.1152/ajprenal.00503.2005 [Abstract] [Full Text] [PDF]  

Giovanna Giannico, Pedro Cortes, Mohammed H. Baccora, Clare Hassett, David W. Taube, and Jerry Yee

Glibenclamide prevents increased extracellular matrix formation induced by high glucose concentration in mesangial cells
Am J Physiol Renal Physiol 292: F57-F65, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00210.2006 [Abstract] [Full Text] [PDF]  

Elaine M. Worcester, Daniel L. Gillen, Andrew P. Evan, Joan H. Parks, Katrina Wright, Linda Trumbore, Yasushi Nakagawa, and Fredric L. Coe

Evidence that postprandial reduction of renal calcium reabsorption mediates hypercalciuria of patients with calcium nephrolithiasis
Am J Physiol Renal Physiol 292: F66-F75, 2007; doi:10.1152/ajprenal.00115.2006 [Abstract] [Full Text] [PDF]  

INVITED REVIEWS:

Sylvie Breton and Dennis Brown

New insights into the regulation of V-ATPase-dependent proton secretion
Am J Physiol Renal Physiol 292: F1-F10, 2007. First published October 10, 2006; doi:10.1152/ajprenal.00340.2006 [Abstract] [Full Text] [PDF]  

ARTICLES:

Helen R. Lock, Steven H. Sacks, and Michael G. Robson

Rapamycin at subimmunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production
Am J Physiol Renal Physiol 292: F76-F81, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00128.2006 [Abstract] [Full Text] [PDF]  

Hossam A. Shaltout, Brian M. Westwood, David B. Averill, Carlos M. Ferrario, Jorge P. Figueroa, Debra I. Diz, James C. Rose, and Mark C. Chappell

Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II
Am J Physiol Renal Physiol 292: F82-F91, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00139.2006 [Abstract] [Full Text] [PDF]  

Clarice K. Fujihara, Gláucia R. Antunes, Ana L. Mattar, Denise M. A. C. Malheiros, José M. Vieira, Jr., and Roberto Zatz

Chronic inhibition of nuclear factor-B attenuates renal injury in the 5/6 renal ablation model
Am J Physiol Renal Physiol 292: F92-F99, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00184.2006 [Abstract] [Full Text] [PDF]  

Ki-Hwan Han, U-Young Lee, Yoon-Seong Jang, Yoon Mi Cho, Young Min Jang, In-A Hwang, Jung Yeon Ghee, Sun-Woo Lim, Wan-Young Kim, Chul Woo Yang, Jin Kim, and Oh-Joo Kwon

Differential regulation of B/K protein expression in proximal and distal tubules of rat kidneys with ischemia-reperfusion injury
Am J Physiol Renal Physiol 292: F100-F106, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00009.2006 [Abstract] [Full Text] [PDF]  

Jun Xie and Qing Guo

Par-4 is a novel mediator of renal tubule cell death in models of ischemia-reperfusion injury
Am J Physiol Renal Physiol 292: F107-F115, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00083.2006 [Abstract] [Full Text] [PDF]  

Carlos A. Roncal, Wei Mu, Byron Croker, Sirirat Reungjui, Xiaosen Ouyang, Isabelle Tabah-Fisch, Richard J. Johnson, and A. Ahsan Ejaz

Effect of elevated serum uric acid on cisplatin-induced acute renal failure
Am J Physiol Renal Physiol 292: F116-F122, 2007; doi:10.1152/ajprenal.00160.2006 [Abstract] [Full Text] [PDF]  

Elena E. Ustinova, Dmitriy W. Gutkin, and Michael A. Pezzone

Sensitization of pelvic nerve afferents and mast cell infiltration in the urinary bladder following chronic colonic irritation is mediated by neuropeptides
Am J Physiol Renal Physiol 292: F123-F130, 2007. First published August 22, 2006; doi:10.1152/ajprenal.00162.2006 [Abstract] [Full Text] [PDF]  

Jazmin Pérez-Rojas, Jorge A. Blanco, Cristino Cruz, Joyce Trujillo, Vishal S. Vaidya, Norma Uribe, Joseph V. Bonventre, Gerardo Gamba, and Norma A. Bobadilla

Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity
Am J Physiol Renal Physiol 292: F131-F139, 2007. First published July 11, 2006; doi:10.1152/ajprenal.00147.2006 [Abstract] [Full Text] [PDF]  

Norman P. Curthoys, Lynn Taylor, Jason D. Hoffert, and Mark A. Knepper

Proteomic analysis of the adaptive response of rat renal proximal tubules to metabolic acidosis
Am J Physiol Renal Physiol 292: F140-F147, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00217.2006 [Abstract] [Full Text] [PDF]  

Rafal Olszanecki, Rita Rezzani, Shinji Omura, David E. Stec, Luigi Rodella, Fady T. Botros, Alvin I. Goodman, George Drummond, and Nader G. Abraham

Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway
Am J Physiol Renal Physiol 292: F148-F157, 2007. First published August 29, 2006; doi:10.1152/ajprenal.00261.2006 [Abstract] [Full Text] [PDF]  

Laura E. Burt, Michael S. Forbes, Barbara A. Thornhill, Susan C. Kiley, and Robert L. Chevalier

Renal vascular endothelial growth factor in neonatal obstructive nephropathy. I. Endogenous VEGF
Am J Physiol Renal Physiol 292: F158-F167, 2007. First published June 20, 2006; doi:10.1152/ajprenal.00293.2005 [Abstract] [Full Text] [PDF]  

Laura E. Burt, Michael S. Forbes, Barbara A. Thornhill, Susan C. Kiley, Jordan J. Minor, and Robert L. Chevalier

Renal vascular endothelial growth factor in neonatal obstructive nephropathy. II. Exogenous VEGF
Am J Physiol Renal Physiol 292: F168-F174, 2007. First published June 20, 2006; doi:10.1152/ajprenal.00294.2005 [Abstract] [Full Text] [PDF]  

Susan K. Fellner and William Arendshorst

Endothelin-A and -B receptors, superoxide, and Ca²⁺ signaling in afferent arterioles
Am J Physiol Renal Physiol 292: F175-F184, 2007. First published June 20, 2006; doi:10.1152/ajprenal.00050.2006 [Abstract] [Full Text] [PDF]  

Erika I. Boesen and David M. Pollock

Acute increases of renal medullary osmolality stimulate endothelin release from the kidney
Am J Physiol Renal Physiol 292: F185-F191, 2007. First published August 15, 2006; doi:10.1152/ajprenal.00021.2006 [Abstract] [Full Text] [PDF]  

Aaron Erdely, Gary Freshour, You-Lin Tain, Kevin Engels, and Chris Baylis

DOCA/NaCl-induced chronic kidney disease: a comparison of renal nitric oxide production in resistant and susceptible rat strains
Am J Physiol Renal Physiol 292: F192-F196, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00146.2006 [Abstract] [Full Text] [PDF]  

Enrico Danzer, Darcie A. Kiddoo, Robert A. Redden, Lauren Robinson, Antoneta Radu, Steve A. Zderic, Edward J. Doolin, N. Scott Adzick, and Alan W. Flake

Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningocele
Am J Physiol Renal Physiol 292: F197-F206, 2007. First published August 29, 2006; doi:10.1152/ajprenal.00001.2006 [Abstract] [Full Text] [PDF]  

Ningjun Li, Fan Yi, Christina M. Sundy, Li Chen, Molly L. Hilliker, Dustin K. Donley, Daniel B. Muldoon, and Pin-Lan Li

Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys
Am J Physiol Renal Physiol 292: F207-F216, 2007. First published August 1, 2006; doi:10.1152/ajprenal.00457.2005 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

P. Kaler and R. Prasad

Molecular cloning and functional characterization of novel zinc transporter rZip10 (Slc39a10) involved in zinc uptake across rat renal brush-border membrane
Am J Physiol Renal Physiol 292: F217-F229, 2007. First published June 27, 2006; doi:10.1152/ajprenal.00014.2006 [Abstract] [Full Text] [PDF]  

Miguel A. Lanaspa, Héctor Giral, Sophia Y. Breusegem, Nabil Halaihel, Goretti Baile, Julia Catalán, José A. Carrodeguas, Nicholas P. Barry, Moshe Levi, and Víctor Sorribas

Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi
Am J Physiol Renal Physiol 292: F230-F242, 2007. First published August 22, 2006; doi:10.1152/ajprenal.00075.2006 [Abstract] [Full Text] [PDF]  

Craig Brooks, Jinzhao Wang, Tianxin Yang, and Zheng Dong

Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells
Am J Physiol Renal Physiol 292: F243-F252, 2007. First published August 1, 2006; doi:10.1152/ajprenal.00236.2006 [Abstract] [Full Text] [PDF]  

J. H. Robben, M. Sze, N. V. A. M. Knoers, and P. M. T. Deen

Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus
Am J Physiol Renal Physiol 292: F253-F260, 2007. First published August 22, 2006; doi:10.1152/ajprenal.00247.2006 [Abstract] [Full Text] [PDF]  

Liping Wu, Manish M. Tiwari, Kurt J. Messer, Joseph H. Holthoff, Neriman Gokden, Robert W. Brock, and Philip R. Mayeux

Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
Am J Physiol Renal Physiol 292: F261-F268, 2007. First published August 22, 2006; doi:10.1152/ajprenal.00263.2006 [Abstract] [Full Text] [PDF]  

Hyun-Wook Lee, Wan-Young Kim, Hyun-Kuk Song, Chul-Woo Yang, Ki-Hwan Han, H. Moo Kwon, and Jin Kim

Sequential expression of NKCC2, TonEBP, aldose reductase, and urea transporter-A in developing mouse kidney
Am J Physiol Renal Physiol 292: F269-F277, 2007. First published August 22, 2006; doi:10.1152/ajprenal.00145.2006 [Abstract] [Full Text] [PDF]  

Rania Nasrallah, Huaqi Xiong, and Richard L. Hébert

Renal prostaglandin E₂ receptor (EP) expression profile is altered in streptozotocin and B6-Ins2^Akita type I diabetic mice
Am J Physiol Renal Physiol 292: F278-F284, 2007. First published September 5, 2006; doi:10.1152/ajprenal.00089.2006 [Abstract] [Full Text] [PDF]  

Li Sun, Yuanzhen Peng, Neeha Zaidi, Ling-Ling Zhu, Jameel Iqbal, Kosj Yamoah, Xin Wang, Peng Liu, Etsuko Abe, Baljit S. Moonga, Solomon Epstein, and Mone Zaidi

Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts
Am J Physiol Renal Physiol 292: F285-F291, 2007. First published September 12, 2006; doi:10.1152/ajprenal.00415.2005 [Abstract] [Full Text] [PDF]  

Zabeena P. Shaik, E. Kim Fifer, and Grazyna Nowak

Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells
Am J Physiol Renal Physiol 292: F292-F303, 2007. First published August 29, 2006; doi:10.1152/ajprenal.00082.2006 [Abstract] [Full Text] [PDF]  

Richard A. Zager, Ali C. M. Johnson, Steven Lund, and Julie Randolph-Habecker

Toll-like receptor (TLR4) shedding and depletion: acute proximal tubular cell responses to hypoxic and toxic injury
Am J Physiol Renal Physiol 292: F304-F312, 2007. First published August 1, 2006; doi:10.1152/ajprenal.00237.2006 [Abstract] [Full Text] [PDF]  

Martin H. de Borst, Mirjan M. van Timmeren, Vishal S. Vaidya, Rudolf A. de Boer, Mario B. A. van Dalen, Andrea B. Kramer, Theo A. Schuurs, Joseph V. Bonventre, Gerjan Navis, and Harry van Goor

Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase
Am J Physiol Renal Physiol 292: F313-F320, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00180.2006 [Abstract] [Full Text] [PDF]  

Patricia Juárez, M. Magdalena Vilchis-Landeros, José Ponce-Coria, Valentín Mendoza, Rogelio Hernández-Pando, Norma A. Bobadilla, and Fernando López-Casillas

Soluble betaglycan reduces renal damage progression in db/db mice
Am J Physiol Renal Physiol 292: F321-F329, 2007. First published September 5, 2006; doi:10.1152/ajprenal.00264.2006 [Abstract] [Full Text] [PDF]  

Yuri Ozawa, Hiroyuki Kobori, Yuki Suzaki, and L. Gabriel Navar

Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions
Am J Physiol Renal Physiol 292: F330-F339, 2007. First published June 27, 2006; doi:10.1152/ajprenal.00059.2006 [Abstract] [Full Text] [PDF]  

Yu-Jung Lee, In-Kyung Song, Kyung-Jin Jang, Jakob Nielsen, Jørgen Frøkiær, Søren Nielsen, and Tae-Hwan Kwon

Increased AQP2 targeting in primary cultured IMCD cells in response to angiotensin II through AT₁ receptor
Am J Physiol Renal Physiol 292: F340-F350, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00090.2006 [Abstract] [Full Text] [PDF]  

Monica Carmosino, Heddwen L. Brooks, Qi Cai, Linda S. Davis, Susan Opalenik, Chuanming Hao, and Matthew D. Breyer

Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct
Am J Physiol Renal Physiol 292: F351-F360, 2007. First published July 11, 2006; doi:10.1152/ajprenal.00049.2006 [Abstract] [Full Text] [PDF]  

Marija Ljubojevic, Daniela Balen, Davorka Breljak, Marija Kusan, Naohiko Anzai, Andrew Bahn, Gerhard Burckhardt, and Ivan Sabolic

Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones
Am J Physiol Renal Physiol 292: F361-F372, 2007. First published August 1, 2006; doi:10.1152/ajprenal.00207.2006 [Abstract] [Full Text] [PDF]  

Ho Jae Han, Min Jin Lim, Yun Jung Lee, Jang Hern Lee, Il Suk Yang, and Mary Taub

Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA₂, and NF-B
Am J Physiol Renal Physiol 292: F373-F381, 2007. First published September 19, 2006; doi:10.1152/ajprenal.00104.2006 [Abstract] [Full Text] [PDF]  

Jakob Nielsen, Tae-Hwan Kwon, Jørgen Frøkiær, Mark A. Knepper, and Søren Nielsen

Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade
Am J Physiol Renal Physiol 292: F382-F394, 2007. First published August 15, 2006; doi:10.1152/ajprenal.00212.2005 [Abstract] [Full Text] [PDF]  

Hiroko Segawa, Setsuko Yamanaka, Akemi Onitsuka, Yuka Tomoe, Masashi Kuwahata, Mikiko Ito, Yutaka Taketani, and Ken-ichi Miyamoto

Parathyroid hormone-dependent endocytosis of renal type IIc Na-P_i cotransporter
Am J Physiol Renal Physiol 292: F395-F403, 2007. First published September 19, 2006; doi:10.1152/ajprenal.00100.2006 [Abstract] [Full Text] [PDF]  

Whaseon Lee-Kwon, Jae Hwan Goo, Zhong Zhang, Erik P. Silldorff, and Thomas L. Pallone

Vasa recta voltage-gated Na⁺ channel Na_v1.3 is regulated by calmodulin
Am J Physiol Renal Physiol 292: F404-F414, 2007. First published August 15, 2006; doi:10.1152/ajprenal.00070.2006 [Abstract] [Full Text] [PDF]  

Soo Mi Kim, Limeng Chen, Diane Mizel, Yuning G. Huang, Josie P. Briggs, and Jurgen Schnermann

Low plasma renin and reduced renin secretory responses to acute stimuli in conscious COX-2-deficient mice
Am J Physiol Renal Physiol 292: F415-F422, 2007. First published September 5, 2006; doi:10.1152/ajprenal.00317.2006 [Abstract] [Full Text] [PDF]  

Laura G. Sánchez-Lozada, Edilia Tapia, Adriana Jiménez, Pablo Bautista, Magdalena Cristóbal, Tomás Nepomuceno, Virgilia Soto, Carmen Ávila-Casado, Takahiko Nakagawa, Richard J. Johnson, Jaime Herrera-Acosta, and Martha Franco

Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats
Am J Physiol Renal Physiol 292: F423-F429, 2007. First published August 29, 2006; doi:10.1152/ajprenal.00124.2006 [Abstract] [Full Text] [PDF]  

Matthew J. Lazzara and William M. Deen

Model of albumin reabsorption in the proximal tubule
Am J Physiol Renal Physiol 292: F430-F439, 2007. First published September 5, 2006; doi:10.1152/ajprenal.00010.2006 [Abstract] [Full Text] [PDF]  

Shougang Zhuang, Yan Yan, Rebecca A. Daubert, Jiahuai Han, and Rick G. Schnellmann

ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells
Am J Physiol Renal Physiol 292: F440-F447, 2007. First published August 1, 2006; doi:10.1152/ajprenal.00170.2006 [Abstract] [Full Text] [PDF]  

Anne M. Karinch, Cheng-Mao Lin, QingHe Meng, Ming Pan, and Wiley W. Souba

Glucocorticoids have a role in renal cortical expression of the SNAT3 glutamine transporter during chronic metabolic acidosis
Am J Physiol Renal Physiol 292: F448-F455, 2007. First published September 5, 2006; doi:10.1152/ajprenal.00168.2006 [Abstract] [Full Text] [PDF]  

Wencui Zheng, Jill W. Verlander, I. Jeanette Lynch, Melanie Cash, Jiahong Shao, Lisa R. Stow, Brian D. Cain, I. David Weiner, Susan M. Wall, and Charles S. Wingo

Cellular distribution of the potassium channel KCNQ1 in normal mouse kidney
Am J Physiol Renal Physiol 292: F456-F466, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00087.2006 [Abstract] [Full Text] [PDF]  

David A. Spector, Qing Yang, and James B. Wade

High urea and creatinine concentrations and urea transporter B in mammalian urinary tract tissues
Am J Physiol Renal Physiol 292: F467-F474, 2007. First published July 18, 2006; doi:10.1152/ajprenal.00181.2006 [Abstract] [Full Text] [PDF]  

CALL FOR PAPERS:

Kim E. Wever, Rosalinde Masereeuw, David S. Miller, Xiao M. Hang, and Gert Flik

Endothelin and calciotropic hormones share regulatory pathways in multidrug resistance protein 2-mediated transport
Am J Physiol Renal Physiol 292: F38-F46, 2007. First published August 15, 2006; doi:10.1152/ajprenal.00479.2005 [Abstract] [Full Text] [PDF]  

INNOVATIVE METHODOLOGY:

Almut Grenz, Tobias Eckle, Hua Zhang, Dan Yang Huang, Manfred Wehrmann, Christoph Köhle, Klaus Unertl, Hartmut Osswald, and Holger K. Eltzschig

Use of a hanging-weight system for isolated renal artery occlusion during ischemic preconditioning in mice
Am J Physiol Renal Physiol 292: F475-F485, 2007. First published August 15, 2006; doi:10.1152/ajprenal.00275.2006 [Abstract] [Full Text] [PDF]  

Anikó Náray-Fejes-Tóth and Géza Fejes-Tóth

Novel mouse strain with Cre recombinase in 11-hydroxysteroid dehydrogenase-2-expressing cells
Am J Physiol Renal Physiol 292: F486-F494, 2007. First published August 8, 2006; doi:10.1152/ajprenal.00188.2006 [Abstract] [Full Text] [PDF]  

Michael F. Flessner, Kimberly Credit, Xiarong Li, and Jarred Tanksley

Similitude of transperitoneal permeability in different rodent species
Am J Physiol Renal Physiol 292: F495-F499, 2007. First published July 18, 2006; doi:10.1152/ajprenal.00169.2006 [Abstract] [Full Text] [PDF]  

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