AJP - Renal Physiology -- Table of Contents (January 1 2008, 294 [1])

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EDITORIAL FOCUS:

Jennifer S. Pollock and Pamela K. Carmines: Diabetic nephropathy: nitric oxide and renal medullary hypoxia
Am J Physiol Renal Physiol 294: F28-F29, 2008. First published November 14, 2007; doi:10.1152/ajprenal.00525.2007 [Full Text] [PDF]

Fredrik Palm, Malou Friederich, Per-Ola Carlsson, Peter Hansell, Tom Teerlink, and Per Liss: Reduced nitric oxide in diabetic kidneys due to increased hepatic arginine metabolism: implications for renomedullary oxygen availability
Am J Physiol Renal Physiol 294: F30-F37, 2008. First published October 17, 2007; doi:10.1152/ajprenal.00166.2007 [Abstract] [Full Text] [PDF]

INVITED REVIEWS:

Chris Baylis: Nitric oxide deficiency in chronic kidney disease
Am J Physiol Renal Physiol 294: F1-F9, 2008. First published October 10, 2007; doi:10.1152/ajprenal.00424.2007 [Abstract] [Full Text] [PDF]

Volker Vallon: P2 receptors in the regulation of renal transport mechanisms
Am J Physiol Renal Physiol 294: F10-F27, 2008. First published October 31, 2007; doi:10.1152/ajprenal.00432.2007 [Abstract] [Full Text] [PDF]

ARTICLES:

Rachel Linz, Natalie L. Barnes, Adriana M. Zimnicka, Jack H. Kaplan, Betty Eipper, and Svetlana Lutsenko: Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b^–/– kidney
Am J Physiol Renal Physiol 294: F53-F61, 2008. First published October 10, 2007; doi:10.1152/ajprenal.00314.2007 [Abstract] [Full Text] [PDF] [Supplemental Figure]

Daisuke Son, Ichiro Kojima, Reiko Inagi, Makiko Matsumoto, Toshiro Fujita, and Masaomi Nangaku: Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD: a proteomic analysis
Am J Physiol Renal Physiol 294: F62-F72, 2008. First published October 24, 2007; doi:10.1152/ajprenal.00113.2007 [Abstract] [Full Text] [PDF]

Thomas A. Natoli, Tiffany C. Gareski, William R. Dackowski, Laurie Smith, Nikolay O. Bukanov, Ryan J. Russo, Hervé Husson, Douglas Matthews, Peter Piepenhagen, and Oxana Ibraghimov-Beskrovnaya: Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures
Am J Physiol Renal Physiol 294: F73-F83, 2008. First published October 10, 2007; doi:10.1152/ajprenal.00362.2007 [Abstract] [Full Text] [PDF]

Martha Franco, Rocio Bautista, Oscar Pérez-Méndez, Lidia González, Ursino Pacheco, L. G. Sánchez-Lozada, José Santamaría, Edilia Tapia, Rogelio Monreal, and Flavio Martínez: Renal interstitial adenosine is increased in angiotensin II-induced hypertensive rats
Am J Physiol Renal Physiol 294: F84-F92, 2008. First published October 17, 2007; doi:10.1152/ajprenal.00123.2007 [Abstract] [Full Text] [PDF]

Hassan Chaib, Bethan E. Hoskins, Shazia Ashraf, Meera Goyal, Roger C. Wiggins, and Friedhelm Hildebrandt: Identification of BRAF as a new interactor of PLC ${varepsilon}$ 1, the protein mutated in nephrotic syndrome type 3
Am J Physiol Renal Physiol 294: F93-F99, 2008. First published October 17, 2007; doi:10.1152/ajprenal.00345.2007 [Abstract] [Full Text] [PDF]

Susann Patschan, Jun Chen, Olga Gealekman, Katrina Krupincza, Maureen Wang, Liming Shu, James A. Shayman, and Michael S. Goligorsky: Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells
Am J Physiol Renal Physiol 294: F100-F109, 2008. First published October 10, 2007; doi:10.1152/ajprenal.00261.2007 [Abstract] [Full Text] [PDF]

Jesus H. Dominguez, Jawahar L. Mehta, Dayuan Li, Pengfei Wu, Katherine J. Kelly, C. Subah Packer, Constance Temm, Erin Goss, Liang Cheng, Shaobo Zhang, Carolyn E. Patterson, John W. Hawes, and Richard Peterson: Anti-LOX-1 therapy in rats with diabetes and dyslipidemia: ablation of renal vascular and epithelial manifestations
Am J Physiol Renal Physiol 294: F110-F119, 2008. First published November 7, 2007; doi:10.1152/ajprenal.00013.2007 [Abstract] [Full Text] [PDF]

Frédéric Michel, Serge Simonet, Christine Vayssettes-Courchay, Florence Bertin, Patricia Sansilvestri-Morel, Fabienne Bernhardt, Jérôme Paysant, Jean-Sébastien Silvestre, Bernard I. Levy, Michel Félétou, and Tony J. Verbeuren: Altered TP receptor function in isolated, perfused kidneys of nondiabetic and diabetic ApoE-deficient mice
Am J Physiol Renal Physiol 294: F120-F129, 2008. First published October 17, 2007; doi:10.1152/ajprenal.00111.2007 [Abstract] [Full Text] [PDF]

Teodor G. Paunescu, Nicolas Da Silva, Leileata M. Russo, Mary McKee, Hua A. J. Lu, Sylvie Breton, and Dennis Brown: Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells
Am J Physiol Renal Physiol 294: F130-F138, 2008. First published October 24, 2007; doi:10.1152/ajprenal.00406.2007 [Abstract] [Full Text] [PDF]

Ruchira Singh and Philine Wangemann: Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model
Am J Physiol Renal Physiol 294: F139-F148, 2008. First published October 24, 2007; doi:10.1152/ajprenal.00433.2007 [Abstract] [Full Text] [PDF]

Elsa Sánchez-López, Juan Rodriguez-Vita, Cecile Cartier, Monica Rupérez, Vanesa Esteban, Gisselle Carvajal, Raquel Rodrígues-Díez, Juan José Plaza, Jesús Egido, and Marta Ruiz-Ortega: Inhibitory effect of interleukin-1β on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells
Am J Physiol Renal Physiol 294: F149-F160, 2008. First published November 7, 2007; doi:10.1152/ajprenal.00129.2007 [Abstract] [Full Text] [PDF]

Miguel L. Graciano, Akira Nishiyama, Keith Jackson, Dale M. Seth, Rudy M. Ortiz, Minolfa C. Prieto-Carrasquero, Hiroyuki Kobori, and L. Gabriel Navar: Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension
Am J Physiol Renal Physiol 294: F161-F169, 2008. First published November 7, 2007; doi:10.1152/ajprenal.00281.2007 [Abstract] [Full Text] [PDF]

Adebayo D. Akintola, Zachary L. Crislip, Jeffrey M. Catania, Gang Chen, Warren E. Zimmer, Robert C. Burghardt, and Alan R. Parrish: Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney
Am J Physiol Renal Physiol 294: F170-F176, 2008. First published October 24, 2007; doi:10.1152/ajprenal.00285.2007 [Abstract] [Full Text] [PDF]

Akiyuki Taruno, Naomi Niisato, and Yoshinori Marunaka: Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells
Am J Physiol Renal Physiol 294: F177-F186, 2008. First published October 24, 2007; doi:10.1152/ajprenal.00250.2007 [Abstract] [Full Text] [PDF]

Richard A. Zager, Ali C. M. Johnson, Masayo Naito, and Karol Bomsztyk: Maleate nephrotoxicity: mechanisms of injury and correlates with ischemic/hypoxic tubular cell death
Am J Physiol Renal Physiol 294: F187-F197, 2008. First published October 17, 2007; doi:10.1152/ajprenal.00434.2007 [Abstract] [Full Text] [PDF]

Jyothsna Gattineni, David Sas, Amit Dagan, Vangipuram Dwarakanath, and Michel Baum: Effect of thyroid hormone on the postnatal renal expression of NHE8
Am J Physiol Renal Physiol 294: F198-F204, 2008. First published October 31, 2007; doi:10.1152/ajprenal.00332.2007 [Abstract] [Full Text] [PDF]

Matthew E. Patterson, John J. Mullins, and Kenneth D. Mitchell: Renoprotective effects of neuronal NOS-derived nitric oxide and cyclooxygenase-2 metabolites in transgenic rats with inducible malignant hypertension
Am J Physiol Renal Physiol 294: F205-F211, 2008. First published October 31, 2007; doi:10.1152/ajprenal.00150.2007 [Abstract] [Full Text] [PDF]

Susan K. Fellner and William J. Arendshorst: Angiotensin II-stimulated Ca²⁺ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na⁺/Ca²⁺ exchange
Am J Physiol Renal Physiol 294: F212-F219, 2008. First published October 31, 2007; doi:10.1152/ajprenal.00244.2007 [Abstract] [Full Text] [PDF]

Yingjie Wang, Werner Beck, Reinhold Deppisch, Sally M. Marshall, Nicholas A. Hoenich, and Michael G. Thompson: Differential effects of dialysis and ultrafiltrate from individuals with CKD, with or without diabetes, on platelet phosphatidylserine externalization
Am J Physiol Renal Physiol 294: F220-F228, 2008. First published August 1, 2007; doi:10.1152/ajprenal.00279.2007 [Abstract] [Full Text] [PDF]

Haikun Shi, Daniel Patschan, Gunnar P. H. Dietz, Mathias Bähr, Matthew Plotkin, and Michael S. Goligorsky: Glial cell line-derived neurotrophic growth factor increases motility and survival of cultured mesenchymal stem cells and ameliorates acute kidney injury
Am J Physiol Renal Physiol 294: F229-F235, 2008. First published November 14, 2007; doi:10.1152/ajprenal.00386.2007 [Abstract] [Full Text] [PDF]

Sun-Young Hwang, Connie W. H. Woo, Kathy K. W. Au-Yeung, Yaw L. Siow, Tong Y. Zhu, and Karmin O: Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor- ${kappa}$ B activation
Am J Physiol Renal Physiol 294: F236-F244, 2008. First published October 31, 2007; doi:10.1152/ajprenal.00331.2007 [Abstract] [Full Text] [PDF]

Yuehan Zhou and Walter F. Boron: Role of endogenously secreted angiotensin II in the CO₂-induced stimulation of HCO₃ reabsorption by renal proximal tubules
Am J Physiol Renal Physiol 294: F245-F252, 2008. First published October 3, 2007; doi:10.1152/ajprenal.00168.2007 [Abstract] [Full Text] [PDF]

J. W. A. M. Celie, R. M. Reijmers, E. M. Slot, R. H. J. Beelen, M. Spaargaren, P. M. ter Wee, S. Florquin, and J. van den Born: Tubulointerstitial heparan sulfate proteoglycan changes in human renal diseases correlate with leukocyte influx and proteinuria
Am J Physiol Renal Physiol 294: F253-F263, 2008. First published November 21, 2007; doi:10.1152/ajprenal.00429.2007 [Abstract] [Full Text] [PDF]

Dong-Jin Oh, Belda Dursun, Zhibin He, Lawrence Lu, Thomas S. Hoke, Danica Ljubanovic, Sarah Faubel, and Charles L. Edelstein: Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice
Am J Physiol Renal Physiol 294: F264-F271, 2008. First published November 14, 2007; doi:10.1152/ajprenal.00204.2007 [Abstract] [Full Text] [PDF]

Eun Hui Bae, Kyun Sang Lee, JongUn Lee, Seong Kwon Ma, Nam Ho Kim, Ki Chul Choi, Jørgen Frøkiær, Søren Nielsen, Sun Young Kim, Sung Zoo Kim, Suhn Hee Kim, and Soo Wan Kim: Effects of ${alpha}$ -lipoic acid on ischemia-reperfusion-induced renal dysfunction in rats
Am J Physiol Renal Physiol 294: F272-F280, 2008. First published November 21, 2007; doi:10.1152/ajprenal.00352.2007 [Abstract] [Full Text] [PDF]

Samy L. Habib, Daniel J. Riley, Lenin Mahimainathan, Basant Bhandari, Goutam Ghosh Choudhury, and Hanna E. Abboud: Tuberin regulates the DNA repair enzyme OGG1
Am J Physiol Renal Physiol 294: F281-F290, 2008. First published November 7, 2007; doi:10.1152/ajprenal.00370.2007 [Abstract] [Full Text] [PDF]

CALL FOR PAPERS:

Oleh Pochynyuk, Vladislav Bugaj, Alain Vandewalle, and James D. Stockand: Purinergic control of apical plasma membrane PI(4,5)P₂ levels sets ENaC activity in principal cells
Am J Physiol Renal Physiol 294: F38-F46, 2008. First published October 3, 2007; doi:10.1152/ajprenal.00403.2007 [Abstract] [Full Text] [PDF]

Marcelo D. Carattino, Christopher J. Passero, Carlos A. Steren, Ahmad B. Maarouf, Joseph M. Pilewski, Mike M. Myerburg, Rebecca P. Hughey, and Thomas R. Kleyman: Defining an inhibitory domain in the ${alpha}$ -subunit of the epithelial sodium channel
Am J Physiol Renal Physiol 294: F47-F52, 2008. First published November 21, 2007; doi:10.1152/ajprenal.00399.2007 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Cover: Lysosomal permeability after incubation with glycated collagen as assessed by decreased co-localization of dextran-Texas red with Lamp-1. Human umbilical vein endothelial cells (HUVEC) were incubated for 24 h in culture medium containing dextran conjugated to Texas red (MW 10,000) followed by a 24-h chase in a dextran-free culture medium for accumulation in lysosomes. Cells were incubated with glycated collagen (GC), native/glycated collagen (1:3 GC), native collagen (NC), or remained untreated (control) and studied at the indicated times. Displayed is a cell treated with chloroquine (300 mM), which was used as a positive control. Cells were fixed, permeabilized, and stained with antibody to Lamp-1 and a nuclear stain, Hoechst 33342. Cells were imaged using a Nikon TE-2000U microscope equipped with a Spot Insight camera (Diagnostic Instruments). See related article by Patschan SA, Chen J, Gealekman O, Krupincza K, Wang M, Shu L, Shayman JA, and Goligorsky MS. Mapping mechanisms and charting the time course of premature senescence and apoptosis: lysosomal dysfunction and gangioside accumulation in endothelial cells. Am J Physiol Renal Physiol. 294: F100–F110, 2008.