AJP - Renal Physiology -- Table of Contents (February 1 2008, 294 [2])

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EDITORIAL FOCUS:

Rudy M. Ortiz: Delineating the contributions of AT_1a and AT_1b receptor-mediated uptake of ANG II in kidneys and adrenals
Am J Physiol Renal Physiol 294: F291-F292, 2008. First published December 12, 2007; doi:10.1152/ajprenal.00589.2007 [Full Text] [PDF]

Xiao C. Li and Jia L. Zhuo: In vivo regulation of AT_1a receptor-mediated intracellular uptake of [¹²⁵I]Val⁵-ANG II in the kidneys and adrenals of AT_1a receptor-deficient mice
Am J Physiol Renal Physiol 294: F293-F302, 2008. First published November 28, 2007; doi:10.1152/ajprenal.00398.2007 [Abstract] [Full Text] [PDF]

TRANSLATIONAL PHYSIOLOGY:

Rajiv Agarwal and Robert P. Light: Arterial stiffness and interdialytic weight gain influence ambulatory blood pressure patterns in hemodialysis patients
Am J Physiol Renal Physiol 294: F303-F308, 2008. First published December 26, 2007; doi:10.1152/ajprenal.00575.2007 [Abstract] [Full Text] [PDF]

ARTICLES:

Joo Lee Cham and Emilio Badoer: Hypothalamic paraventricular nucleus is critical for renal vasoconstriction elicited by elevations in body temperature
Am J Physiol Renal Physiol 294: F309-F315, 2008. First published December 12, 2007; doi:10.1152/ajprenal.00488.2007 [Abstract] [Full Text] [PDF]

Nan-Hsiung Feng, Hsang-Hsing Lee, Jeng-Chaun Shiang, and Ming-Chieh Ma: Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys
Am J Physiol Renal Physiol 294: F316-F325, 2008. First published November 21, 2007; doi:10.1152/ajprenal.00308.2007 [Abstract] [Full Text] [PDF]

Hiroyuki Ohnishi, Shinya Mizuno, and Toshikazu Nakamura: Inhibition of tubular cell proliferation by neutralizing endogenous HGF leads to renal hypoxia and bone marrow-derived cell engraftment in acute renal failure
Am J Physiol Renal Physiol 294: F326-F335, 2008. First published November 21, 2007; doi:10.1152/ajprenal.00480.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]

Yasmir Quiroz, Atilio Ferrebuz, Freddy Romero, Nosratola D. Vaziri, and Bernardo Rodriguez-Iturbe: Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction
Am J Physiol Renal Physiol 294: F336-F344, 2008. First published December 12, 2007; doi:10.1152/ajprenal.00500.2007 [Abstract] [Full Text] [PDF]

Huda Ismail Abdullah, Paulina L. Pedraza, John C. McGiff, and Nicholas R. Ferreri: CaR activation increases TNF production by mTAL cells via a G_i-dependent mechanism
Am J Physiol Renal Physiol 294: F345-F354, 2008. First published November 21, 2007; doi:10.1152/ajprenal.00509.2006 [Abstract] [Full Text] [PDF]

Phulwinder K. Grover, Lauren A. Thurgood, David E. Fleming, Wilhelm van Bronswijk, Tingting Wang, and Rosemary L. Ryall: Intracrystalline urinary proteins facilitate degradation and dissolution of calcium oxalate crystals in cultured renal cells
Am J Physiol Renal Physiol 294: F355-F361, 2008. First published December 12, 2007; doi:10.1152/ajprenal.00529.2007 [Abstract] [Full Text] [PDF]

Mattias Carlström, Russell D. Brown, Jenny Edlund, Johan Sällström, Erik Larsson, Tom Teerlink, Fredrik Palm, Nils Wåhlin, and A. Erik G. Persson: Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals
Am J Physiol Renal Physiol 294: F362-F370, 2008. First published November 21, 2007; doi:10.1152/ajprenal.00410.2007 [Abstract] [Full Text] [PDF] [Corrigendum]

H. Thomas Lee, Mihwa Kim, Joseph H. Song, Sean W. C. Chen, Gina Gubitosa, and Charles W. Emala: Sevoflurane-mediated TGF-β₁ signaling in renal proximal tubule cells
Am J Physiol Renal Physiol 294: F371-F378, 2008. First published December 5, 2007; doi:10.1152/ajprenal.00277.2007 [Abstract] [Full Text] [PDF]

Peter E. Westerweel, Krista den Ouden, Tri Q. Nguyen, Roel Goldschmeding, Jaap A. Joles, and Marianne C. Verhaar: Amelioration of anti-Thy1-glomerulonephritis by PPAR- ${gamma}$ agonism without increase of endothelial progenitor cell homing
Am J Physiol Renal Physiol 294: F379-F384, 2008. First published December 12, 2007; doi:10.1152/ajprenal.00019.2007 [Abstract] [Full Text] [PDF]

Edgar A. Jaimes, Ming-Sheng Zhou, Damien D. Pearse, Leopold Puzis, and Leopoldo Raij: Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species
Am J Physiol Renal Physiol 294: F385-F392, 2008. First published December 19, 2007; doi:10.1152/ajprenal.00302.2007 [Abstract] [Full Text] [PDF]

Cécile Rahuel, Anne Filipe, Léa Ritie, Wassim El Nemer, Natacha Patey-Mariaud, Dominique Eladari, Jean-Pierre Cartron, Patricia Simon-Assmann, Caroline Le Van Kim, and Yves Colin: Genetic inactivation of the laminin ${alpha}$ ₅ chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse
Am J Physiol Renal Physiol 294: F393-F406, 2008. First published November 21, 2007; doi:10.1152/ajprenal.00315.2007 [Abstract] [Full Text] [PDF]

Klaudia Giehl, Angela Graness, and Margarete Goppelt-Struebe: The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression
Am J Physiol Renal Physiol 294: F407-F413, 2008. First published November 28, 2007; doi:10.1152/ajprenal.00093.2007 [Abstract] [Full Text] [PDF]

Adriana Castello Costa Girardi, Lívia Emy Fukuda, Luciana Venturini Rossoni, Gerhard Malnic, and Nancy Amaral Rebouças: Dipeptidyl peptidase IV inhibition downregulates Na⁺-H⁺ exchanger NHE3 in rat renal proximal tubule
Am J Physiol Renal Physiol 294: F414-F422, 2008. First published December 12, 2007; doi:10.1152/ajprenal.00174.2007 [Abstract] [Full Text] [PDF]

Zabeena P. Shaik, E. Kim Fifer, and Grazyna Nowak: Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury
Am J Physiol Renal Physiol 294: F423-F432, 2008. First published December 12, 2007; doi:10.1152/ajprenal.00463.2007 [Abstract] [Full Text] [PDF]

Bing Yao, Jie Xu, Raymond C. Harris, and Ming-Zhi Zhang: Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase
Am J Physiol Renal Physiol 294: F433-F439, 2008. First published December 5, 2007; doi:10.1152/ajprenal.00436.2007 [Abstract] [Full Text] [PDF]

Stephanie Krämer, Yingrui Wang-Rosenke, Valeska Scholl, Eva Binder, Tanja Loof, Dmytro Khadzhynov, Hiroshi Kawachi, Fujio Shimizu, Fritz Diekmann, Klemens Budde, Hans-H. Neumayer, and Harm Peters: Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat
Am J Physiol Renal Physiol 294: F440-F449, 2008. First published December 19, 2007; doi:10.1152/ajprenal.00379.2007 [Abstract] [Full Text] [PDF]

INNOVATIVE METHODOLOGY:

David J. Kennedy, Jihad Elkareh, Amjad Shidyak, Anna P. Shapiro, Sleiman Smaili, Krishna Mutgi, Shalini Gupta, Jiang Tian, Eric Morgan, Samer Khouri, Christopher J. Cooper, Sankaridrug M. Periyasamy, Zijian Xie, Deepak Malhotra, Olga V. Fedorova, Alexei Y. Bagrov, and Joseph I. Shapiro: Partial nephrectomy as a model for uremic cardiomyopathy in the mouse
Am J Physiol Renal Physiol 294: F450-F454, 2008. First published November 21, 2007; doi:10.1152/ajprenal.00472.2007 [Abstract] [Full Text] [PDF]

CORRIGENDA:

: Corrigendum
Am J Physiol Renal Physiol 294: F455-F456, 2008; doi:10.1152/ajprenal.zh2-5020-corr.2008 [Full Text] [PDF]

Cover Caption:

Cover

Cover: Lysosomal permeability after incubation with glycated collagen as assessed by decreased co-localization of dextran-Texas red with Lamp-1. Human umbilical vein endothelial cells (HUVEC) were incubated for 24 h in culture medium containing dextran conjugated to Texas red (MW 10,000) followed by a 24-h chase in a dextran-free culture medium for accumulation in lysosomes. Cells were incubated with glycated collagen (GC), native/glycated collagen (1:3 GC), native collagen (NC), or remained untreated (control) and studied at the indicated times. Displayed is a cell treated with chloroquine (300 mM), which was used as a positive control. Cells were fixed, permeabilized, and stained with antibody to Lamp-1 and a nuclear stain, Hoechst 33342. Cells were imaged using a Nikon TE-2000U microscope equipped with a Spot Insight camera (Diagnostic Instruments). See related article by Patschan SA, Chen J, Gealekman O, Krupincza K, Wang M, Shu L, Shayman JA, and Goligorsky MS. Mapping mechanisms and charting the time course of premature senescence and apoptosis: lysosomal dysfunction and gangioside accumulation in endothelial cells. Am J Physiol Renal Physiol. 294: F100–F110, 2008.