EDITORIAL FOCUS:

V. Matti Vehaskari

Programming of hypertension: the nervous kidney
Am J Physiol Renal Physiol 295: F27-F28, 2008. First published May 7, 2008; doi:10.1152/ajprenal.90270.2008 [Full Text] [PDF]  

Amit Dagan, H. Moo Kwon, Vangipuram Dwarakanath, and Michel Baum

Effect of renal denervation on prenatal programming of hypertension and renal tubular transporter abundance
Am J Physiol Renal Physiol 295: F29-F34, 2008. First published April 9, 2008; doi:10.1152/ajprenal.00123.2008 [Abstract] [Full Text] [PDF]  

Hayo Castrop

Modulation of adenosine receptor expression in the proximal tubule: a novel adaptive mechanism to regulate renal salt and water metabolism
Am J Physiol Renal Physiol 295: F35-F36, 2008. First published May 14, 2008; doi:10.1152/ajprenal.90299.2008 [Full Text] [PDF]  

Aaron Kulick, Carolina Panico, Pritmohinder Gill, and William J. Welch

Low salt intake increases adenosine type 1 receptor expression and function in the rat proximal tubule
Am J Physiol Renal Physiol 295: F37-F41, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00061.2008 [Abstract] [Full Text] [PDF]  

David Sheikh-Hamad

Cisplatin-induced cytoxicity: is the nucleus relevant?
Am J Physiol Renal Physiol 295: F42-F43, 2008. First published May 14, 2008; doi:10.1152/ajprenal.90293.2008 [Full Text] [PDF]  

Fang Yu, Judit Megyesi, and Peter M. Price

Cytoplasmic initiation of cisplatin cytotoxicity
Am J Physiol Renal Physiol 295: F44-F52, 2008. First published April 9, 2008; doi:10.1152/ajprenal.00593.2007 [Abstract] [Full Text] [PDF]  

INVITED REVIEWS:

Mark R. Quinlan, Neil G. Docherty, R. William G. Watson, and John M. Fitzpatrick

Exploring mechanisms involved in renal tubular sensing of mechanical stretch following ureteric obstruction
Am J Physiol Renal Physiol 295: F1-F11, 2008. First published April 9, 2008; doi:10.1152/ajprenal.00576.2007 [Abstract] [Full Text] [PDF]  

Avril A. Morrison, Rebecca L. Viney, Moin A. Saleem, and Michael R. Ladomery

New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes
Am J Physiol Renal Physiol 295: F12-F17, 2008. First published April 2, 2008; doi:10.1152/ajprenal.00597.2007 [Abstract] [Full Text] [PDF]  

ARTICLES:

Ming-Sheng Zhou, Ivonne Hernandez Schuman, Edgar A. Jaimes, and Leopoldo Raij

Renoprotection by statins is linked to a decrease in renal oxidative stress, TGF-β, and fibronectin with concomitant increase in nitric oxide bioavailability
Am J Physiol Renal Physiol 295: F53-F59, 2008. First published May 7, 2008; doi:10.1152/ajprenal.00041.2008 [Abstract] [Full Text] [PDF]  

Marcia R. Saban, Joseph M. Backer, Marina V. Backer, Julie Maier, Ben Fowler, Carole A. Davis, Cindy Simpson, Xue-Ru Wu, Lori Birder, Michael R. Freeman, Shay Soker, Robert E. Hurst, and Ricardo Saban

VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation
Am J Physiol Renal Physiol 295: F60-F72, 2008. First published May 7, 2008; doi:10.1152/ajprenal.00618.2007 [Abstract] [Full Text] [PDF]  

Jayant T. Mathew, Hitesh Patni, Ahmad N. Chaudhary, Wei Liang, Aakriti Gupta, Praveen N. Chander, Guohua Ding, and Pravin C. Singhal

Aldosterone induces mesangial cell apoptosis both in vivo and in vitro
Am J Physiol Renal Physiol 295: F73-F81, 2008. First published May 7, 2008; doi:10.1152/ajprenal.00435.2007 [Abstract] [Full Text] [PDF]  

Min Li, Saravanan Balamuthusamy, Eric E. Simon, and Vecihi Batuman

Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells
Am J Physiol Renal Physiol 295: F82-F90, 2008. First published April 30, 2008; doi:10.1152/ajprenal.00091.2008 [Abstract] [Full Text] [PDF]  

Qun Sha, Wade Pearson, Lauren C. Burcea, Darian A. Wigfall, Paul H. Schlesinger, Colin G. Nichols, and Robert W. Mercer

Human FXYD2 G41R mutation responsible for renal hypomagnesemia behaves as an inward-rectifying cation channel
Am J Physiol Renal Physiol 295: F91-F99, 2008. First published April 30, 2008; doi:10.1152/ajprenal.00519.2007 [Abstract] [Full Text] [PDF]  

Toshinori Aoyagi, Yuichiro Izumi, Masami Hiroyama, Takanobu Matsuzaki, Yukiko Yasuoka, Atsushi Sanbe, Hiroki Miyazaki, Yoko Fujiwara, Yushi Nakayama, Yukimasa Kohda, Junji Yamauchi, Takeaki Inoue, Katsumasa Kawahara, Hideyuki Saito, Kimio Tomita, Hiroshi Nonoguchi, and Akito Tanoue

Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells
Am J Physiol Renal Physiol 295: F100-F107, 2008. First published April 30, 2008; doi:10.1152/ajprenal.00088.2008 [Abstract] [Full Text] [PDF]  

Stephen A. Kempson, Jason M. Edwards, Alyssa Osborn, and Michael Sturek

Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells
Am J Physiol Renal Physiol 295: F108-F117, 2008. First published April 30, 2008; doi:10.1152/ajprenal.00108.2008 [Abstract] [Full Text] [PDF]  

Xiao R. Huang, Arthur C. K. Chung, Xiao J. Wang, Kar Neng Lai, and Hui Y. Lan

Mice overexpressing latent TGF-β1 are protected against renal fibrosis in obstructive kidney disease
Am J Physiol Renal Physiol 295: F118-F127, 2008. First published April 30, 2008; doi:10.1152/ajprenal.00021.2008 [Abstract] [Full Text] [PDF]  

H. Thomas Lee, Sean W. C. Chen, Thomas C. Doetschman, Chuxia Deng, Vivette D. D'Agati, and Mihwa Kim

Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-β₁ pathway
Am J Physiol Renal Physiol 295: F128-F136, 2008. First published April 23, 2008; doi:10.1152/ajprenal.00577.2007 [Abstract] [Full Text] [PDF]  

Grzegorz Piecha, Nadezda Koleganova, Marie-Luise Gross, Aman Geldyyev, Marcin Adamczak, and Eberhard Ritz

Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination
Am J Physiol Renal Physiol 295: F137-F144, 2008. First published April 23, 2008; doi:10.1152/ajprenal.00065.2008 [Abstract] [Full Text] [PDF]  

Jingping Xing, Zhu Zhang, Haiping Mao, Rick G. Schnellmann, and Shougang Zhuang

Src regulates cell cycle protein expression and renal epithelial cell proliferation via PI3K/Akt signaling-dependent and -independent mechanisms
Am J Physiol Renal Physiol 295: F145-F152, 2008. First published April 23, 2008; doi:10.1152/ajprenal.00092.2008 [Abstract] [Full Text] [PDF]  

Fangfang Peng, Baifang Zhang, Dongcheng Wu, Alistair J. Ingram, Bo Gao, and Joan C. Krepinsky

TGFβ-induced RhoA activation and fibronectin production in mesangial cells require caveolae
Am J Physiol Renal Physiol 295: F153-F164, 2008. First published April 23, 2008; doi:10.1152/ajprenal.00419.2007 [Abstract] [Full Text] [PDF]  

Masayo Aoki, Tomohiro Terada, Moto Kajiwara, Ken Ogasawara, Iwao Ikai, Osamu Ogawa, Toshiya Katsura, and Ken-ichi Inui

Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation
Am J Physiol Renal Physiol 295: F165-F170, 2008. First published May 28, 2008; doi:10.1152/ajprenal.90257.2008 [Abstract] [Full Text] [PDF]  

Carmen M. Troncoso Brindeiro, Rachel W. Fallet, Pascale H. Lane, and Pamela K. Carmines

Potassium channel contributions to afferent arteriolar tone in normal and diabetic rat kidney
Am J Physiol Renal Physiol 295: F171-F178, 2008. First published May 21, 2008; doi:10.1152/ajprenal.00563.2007 [Abstract] [Full Text] [PDF]  

Carole Doucet, Serge Milin, Frederic Favreau, Thibault Desurmont, Emilie Manguy, William Hébrard, Yuriyo Yamamoto, Gérard Mauco, Michel Eugene, Vassilios Papadopoulos, Thierry Hauet, and Jean Michel Goujon

A p38 mitogen-activated protein kinase inhibitor protects against renal damage in a non-heart-beating donor model
Am J Physiol Renal Physiol 295: F179-F191, 2008. First published April 30, 2008; doi:10.1152/ajprenal.00252.2007 [Abstract] [Full Text] [PDF]  

Chung-Lin Chou, Ming-Jiun Yu, Eliza M. Kassai, Ryan G. Morris, Jason D. Hoffert, Susan M. Wall, and Mark A. Knepper

Roles of basolateral solute uptake via NKCC1 and of myosin II in vasopressin-induced cell swelling in inner medullary collecting duct
Am J Physiol Renal Physiol 295: F192-F201, 2008. First published April 16, 2008; doi:10.1152/ajprenal.00011.2008 [Abstract] [Full Text] [PDF]  

Haiping Mao, Zhilian Li, Yi Zhou, Zhijian Li, Shougang Zhuang, Xin An, Baiyu Zhang, Wei Chen, Jing Nie, Zhiyong Wang, Steven C. Borkan, Yihan Wang, and Xueqing Yu

HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy
Am J Physiol Renal Physiol 295: F202-F214, 2008. First published April 16, 2008; doi:10.1152/ajprenal.00468.2007 [Abstract] [Full Text] [PDF]  

Jayesh J. Kattla, Rosemarie M. Carew, Mediha Heljic, Catherine Godson, and Derek P. Brazil

Protein kinase B/Akt activity is involved in renal TGF-β1-driven epithelial-mesenchymal transition in vitro and in vivo
Am J Physiol Renal Physiol 295: F215-F225, 2008. First published May 21, 2008; doi:10.1152/ajprenal.00548.2007 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Kanishka Mohib, Shuang Wang, Qiunong Guan, Andrew L. Mellor, Hongtao Sun, Caigan Du, and Anthony M. Jevnikar

Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury
Am J Physiol Renal Physiol 295: F226-F234, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00567.2007 [Abstract] [Full Text] [PDF]  

Eun Young Kim, Kyoung-Jae Choi, and Stuart E. Dryer

Nephrin binds to the COOH terminus of a large-conductance Ca²⁺-activated K⁺ channel isoform and regulates its expression on the cell surface
Am J Physiol Renal Physiol 295: F235-F246, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00140.2008 [Abstract] [Full Text] [PDF]  

Jiarong Chen, Tomohiro Terada, Ken Ogasawara, Toshiya Katsura, and Ken-ichi Inui

Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis
Am J Physiol Renal Physiol 295: F247-F252, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00139.2008 [Abstract] [Full Text] [PDF]  

Xiaohua Shi, Hong Qu, Matthias Kretzler, and Chuanyue Wu

Roles of PINCH-2 in regulation of glomerular cell shape change and fibronectin matrix deposition
Am J Physiol Renal Physiol 295: F253-F263, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00070.2008 [Abstract] [Full Text] [PDF]  

Minoru Miyazato, Yasuhiro Kaiho, Izumi Kamo, Michael B. Chancellor, Kimio Sugaya, William C. de Groat, and Naoki Yoshimura

Effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on sneeze-induced urethral continence reflex in rats
Am J Physiol Renal Physiol 295: F264-F271, 2008. First published May 14, 2008; doi:10.1152/ajprenal.90241.2008 [Abstract] [Full Text] [PDF]  

Xuemei Wang, Kosuke Takeya, Philip I. Aaronson, Kathy Loutzenhiser, and Rodger Loutzenhiser

Effects of amiloride, benzamil, and alterations in extracellular Na⁺ on the rat afferent arteriole and its myogenic response
Am J Physiol Renal Physiol 295: F272-F282, 2008. First published May 21, 2008; doi:10.1152/ajprenal.00200.2007 [Abstract] [Full Text] [PDF]  

Ryousuke Satou, Romer A. Gonzalez-Villalobos, Kayoko Miyata, Naro Ohashi, Akemi Katsurada, L. Gabriel Navar, and Hiroyuki Kobori

Costimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells
Am J Physiol Renal Physiol 295: F283-F289, 2008. First published May 7, 2008; doi:10.1152/ajprenal.00047.2008 [Abstract] [Full Text] [PDF]  

CALL FOR PAPERS:

Anikó Náray-Fejes-Tóth, Cary Boyd, and Géza Fejes-Tóth

Regulation of epithelial sodium transport by promyelocytic leukemia zinc finger protein
Am J Physiol Renal Physiol 295: F18-F26, 2008. First published April 30, 2008; doi:10.1152/ajprenal.00573.2007 [Abstract] [Full Text] [PDF]  

INNOVATIVE METHODOLOGY:

Yu-Jung Lee, Hyo-Jung Choi, Jung-Suk Lim, Ji-Hyun Earm, Byung-Heon Lee, In-San Kim, Jørgen Frøkiær, Søren Nielsen, and Tae-Hwan Kwon

A novel method of ligand peptidomics to identify peptide ligands binding to AQP2-expressing plasma membranes and intracellular vesicles of rat kidney
Am J Physiol Renal Physiol 295: F300-F309, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00006.2008 [Abstract] [Full Text] [PDF]  

Lisa M. Curtis, Sifeng Chen, Bo Chen, Anupam Agarwal, Christopher A. Klug, and Paul W. Sanders

Contribution of intrarenal cells to cellular repair after acute kidney injury: subcapsular implantation technique
Am J Physiol Renal Physiol 295: F310-F314, 2008. First published April 30, 2008; doi:10.1152/ajprenal.90205.2008 [Abstract] [Full Text] [PDF]  

Florian Tögel, Ying Yang, Ping Zhang, Zhuma Hu, and Christof Westenfelder

Bioluminescence imaging to monitor the in vivo distribution of administered mesenchymal stem cells in acute kidney injury
Am J Physiol Renal Physiol 295: F315-F321, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00098.2008 [Abstract] [Full Text] [PDF]  

REPORTS:

Hua Jenny Lu, Toshiyuki Matsuzaki, Richard Bouley, Udo Hasler, Quan-Hong Qin, and Dennis Brown

The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells
Am J Physiol Renal Physiol 295: F290-F294, 2008. First published April 23, 2008; doi:10.1152/ajprenal.00072.2008 [Abstract] [Full Text] [PDF]  

Mitsi A. Blount, Abinash C. Mistry, Otto Fröhlich, S. Russ Price, Guangping Chen, Jeff M. Sands, and Janet D. Klein

Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation
Am J Physiol Renal Physiol 295: F295-F299, 2008. First published May 21, 2008; doi:10.1152/ajprenal.00102.2008 [Abstract] [Full Text] [PDF]  

CORRIGENDA:

CORRIGENDUM
Am J Physiol Renal Physiol 295: F322-F322, 2008; doi:10.1152/ajprenal.zh2-5212-corr.2008 [Full Text] [PDF]  

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