EDITORIAL FOCUS:

Moshe Levi

Novel NaPi-2c mutations that cause mistargeting of NaPi-2c protein and uncoupling of Na-P_i cotransport cause HHRH
Am J Physiol Renal Physiol 295: F369-F370, 2008. First published June 4, 2008; doi:10.1152/ajprenal.90327.2008 [Full Text] [PDF]  

TRANSLATIONAL PHYSIOLOGY:

Stephen Walsh, Franck Borgese, Nicole Gabillat, Robert Unwin, and Helene Guizouarn

Cation transport activity of anion exchanger 1 mutations found in inherited distal renal tubular acidosis
Am J Physiol Renal Physiol 295: F343-F350, 2008. First published June 4, 2008; doi:10.1152/ajprenal.00587.2007 [Abstract] [Full Text] [PDF]  

Osun Kwon, Seok-Min Hong, Timothy A. Sutton, and Constance J. Temm

Preservation of peritubular capillary endothelial integrity and increasing pericytes may be critical to recovery from postischemic acute kidney injury
Am J Physiol Renal Physiol 295: F351-F359, 2008. First published June 18, 2008; doi:10.1152/ajprenal.90276.2008 [Abstract] [Full Text] [PDF] [Supplemental Videos]  

Graciana Jaureguiberry, Thomas O. Carpenter, Stuart Forman, Harald Jüppner, and Clemens Bergwitz

A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc
Am J Physiol Renal Physiol 295: F371-F379, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00090.2008 [Abstract] [Full Text] [PDF]  

INVITED REVIEWS:

Masanori Kitamura

Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces
Am J Physiol Renal Physiol 295: F323-F334, 2008. First published March 26, 2008; doi:10.1152/ajprenal.00050.2008 [Abstract] [Full Text] [PDF]  

V. W. S. Lee, Y. M. Wang, Y. P. Wang, D. Zheng, T. Polhill, Q. Cao, H. Wu, I. E. Alexander, S. I. Alexander, and D. C. H. Harris

Regulatory immune cells in kidney disease
Am J Physiol Renal Physiol 295: F335-F342, 2008. First published April 16, 2008; doi:10.1152/ajprenal.00077.2008 [Abstract] [Full Text] [PDF]  

ARTICLES:

Daniel I. Levy, Sherry Wanderling, Daniel Biemesderfer, and Steve A. N. Goldstein

MiRP3 acts as an accessory subunit with the BK potassium channel
Am J Physiol Renal Physiol 295: F380-F387, 2008. First published May 7, 2008; doi:10.1152/ajprenal.00598.2007 [Abstract] [Full Text] [PDF]  

Ho-Shiang Huang, Ming-Chieh Ma, and Jun Chen

Chronic L-arginine administration increases oxidative and nitrosative stress in rat hyperoxaluric kidneys and excessive crystal deposition
Am J Physiol Renal Physiol 295: F388-F396, 2008. First published April 30, 2008; doi:10.1152/ajprenal.00405.2007 [Abstract] [Full Text] [PDF]  

Ewen M. Harrison, Eva Sharpe, Christopher O. Bellamy, Stephen J. McNally, Luke Devey, O. James Garden, James A. Ross, and Stephen J. Wigmore

Heat shock protein 90-binding agents protect renal cells from oxidative stress and reduce kidney ischemia-reperfusion injury
Am J Physiol Renal Physiol 295: F397-F405, 2008. First published June 18, 2008; doi:10.1152/ajprenal.00361.2007 [Abstract] [Full Text] [PDF]  

Wei-Zhong Ying, Kristal Aaron, and Paul W. Sanders

Mechanism of dietary salt-mediated increase in intravascular production of TGF-β1
Am J Physiol Renal Physiol 295: F406-F414, 2008. First published June 18, 2008; doi:10.1152/ajprenal.90294.2008 [Abstract] [Full Text] [PDF]  

Juan A. Ardura, Raúl Berruguete, David Rámila, M. Victoria Alvarez-Arroyo, and Pedro Esbrit

Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney
Am J Physiol Renal Physiol 295: F415-F425, 2008. First published June 11, 2008; doi:10.1152/ajprenal.00018.2008 [Abstract] [Full Text] [PDF]  

Syed J. Khundmiri, Mohammed Ameen, Nicholas A. Delamere, and Eleanor D. Lederer

PTH-mediated regulation of Na⁺-K⁺-ATPase requires Src kinase-dependent ERK phosphorylation
Am J Physiol Renal Physiol 295: F426-F437, 2008. First published June 11, 2008; doi:10.1152/ajprenal.00516.2007 [Abstract] [Full Text] [PDF]  

Hao-Ran Wang, Zhen Liu, and Chou-Long Huang

Domains of WNK1 kinase in the regulation of ROMK1
Am J Physiol Renal Physiol 295: F438-F445, 2008. First published June 11, 2008; doi:10.1152/ajprenal.90287.2008 [Abstract] [Full Text] [PDF]  

Erika I. Boesen, Jennifer M. Sasser, Mohamed A. Saleh, William A. Potter, Mandy Woods, Timothy D. Warner, Jennifer S. Pollock, and David M. Pollock

Interleukin-1β, but not interleukin-6, enhances renal and systemic endothelin production in vivo
Am J Physiol Renal Physiol 295: F446-F453, 2008. First published June 4, 2008; doi:10.1152/ajprenal.00095.2008 [Abstract] [Full Text] [PDF]  

Y. Ikeda and A. Kanai

Urotheliogenic modulation of intrinsic activity in spinal cord-transected rat bladders: role of mucosal muscarinic receptors
Am J Physiol Renal Physiol 295: F454-F461, 2008. First published June 11, 2008; doi:10.1152/ajprenal.90315.2008 [Abstract] [Full Text] [PDF]  

Peijun P. Shi, Xiao R. Cao, Eileen M. Sweezer, Thomas S. Kinney, Nathan R. Williams, Russell F. Husted, Ramesh Nair, Robert M. Weiss, Roger A. Williamson, Curt D. Sigmund, Peter M. Snyder, Olivier Staub, John B. Stokes, and Baoli Yang

Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2
Am J Physiol Renal Physiol 295: F462-F470, 2008. First published June 4, 2008; doi:10.1152/ajprenal.90300.2008 [Abstract] [Full Text] [PDF] [Supplemental Video and Other Materialss]  

Merav Ingbir, Idit F. Schwartz, Alexander Shtabsky, Irina Filip, Ran Reshef, Tamara Chernichovski, Nomi Levin-Iaina, Uri Rozovski, Yoram Levo, and Doron Schwartz

Rosiglitazone improves aortic arginine transport, through inhibition of PKC, in uremic rats
Am J Physiol Renal Physiol 295: F471-F477, 2008. First published June 4, 2008; doi:10.1152/ajprenal.00619.2007 [Abstract] [Full Text] [PDF]  

Lucia Torielli, Simona Tivodar, Rosa Chiara Montella, Roberto Iacone, Gloria Padoani, Paolo Tarsini, Ornella Russo, Daniela Sarnataro, Pasquale Strazzullo, Patrizia Ferrari, Giuseppe Bianchi, and Chiara Zurzolo

-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption
Am J Physiol Renal Physiol 295: F478-F487, 2008. First published June 4, 2008; doi:10.1152/ajprenal.90226.2008 [Abstract] [Full Text] [PDF]  

Terrence Kucic, Ian B. Copland, Jessica Cuerquis, Daniel L. Coutu, Lorraine E. Chalifour, Raymonde F. Gagnon, and Jacques Galipeau

Mesenchymal stromal cells genetically engineered to overexpress IGF-I enhance cell-based gene therapy of renal failure-induced anemia
Am J Physiol Renal Physiol 295: F488-F496, 2008. First published June 4, 2008; doi:10.1152/ajprenal.00044.2008 [Abstract] [Full Text] [PDF]  

Guixian Wang, Chunling Li, Soo Wan Kim, Troels Ring, Jianguo Wen, Jens Christian Djurhuus, Weidong Wang, Søren Nielsen, and Jørgen Frøkiær

Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney
Am J Physiol Renal Physiol 295: F497-F506, 2008. First published May 28, 2008; doi:10.1152/ajprenal.00425.2007 [Abstract] [Full Text] [PDF]  

Gerald P. McCafferty, Blake A. Misajet, Nicholas J. Laping, Richard M. Edwards, and Kevin S. Thorneloe

Enhanced bladder capacity and reduced prostaglandin E₂-mediated bladder hyperactivity in EP3 receptor knockout mice
Am J Physiol Renal Physiol 295: F507-F514, 2008. First published May 28, 2008; doi:10.1152/ajprenal.00054.2008 [Abstract] [Full Text] [PDF]  

Steven D. Crowley, Campbell W. Frey, Samantha K. Gould, Robert Griffiths, Phillip Ruiz, James L. Burchette, David N. Howell, Natalia Makhanova, Ming Yan, Hyung-Suk Kim, Pierre-Louis Tharaux, and Thomas M. Coffman

Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension
Am J Physiol Renal Physiol 295: F515-F524, 2008. First published May 21, 2008; doi:10.1152/ajprenal.00527.2007 [Abstract] [Full Text] [PDF]  

Yuedan Li, Irene B. M. Konings, Jun Zhao, Leo S. Price, Emile de Heer, and Peter M. T. Deen

Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2
Am J Physiol Renal Physiol 295: F525-F533, 2008. First published May 21, 2008; doi:10.1152/ajprenal.00448.2007 [Abstract] [Full Text] [PDF]  

Tarek M. El-Achkar, Xue-Ru Wu, Michael Rauchman, Ruth McCracken, Susan Kiefer, and Pierre C. Dagher

Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression
Am J Physiol Renal Physiol 295: F534-F544, 2008. First published May 21, 2008; doi:10.1152/ajprenal.00083.2008 [Abstract] [Full Text] [PDF]  

Una J. Lee, A. Marcus Gustilo-Ashby, Firouz Daneshgari, Mei Kuang, Drina Vurbic, Dan Li Lin, Chris A. Flask, Tiansen Li, and Margot S. Damaser

Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans
Am J Physiol Renal Physiol 295: F545-F555, 2008. First published May 21, 2008; doi:10.1152/ajprenal.00063.2008 [Abstract] [Full Text] [PDF]  

Giovambattista Capasso, Maria Rizzo, Maria Lisa Garavaglia, Francesco Trepiccione, Miriam Zacchia, Alessandra Mugione, Patrizia Ferrari, Markus Paulmichl, Florian Lang, Johannes Loffing, Monique Carrel, Sara Damiano, Carsten A. Wagner, Giuseppe Bianchi, and Giuliano Meyer

Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension
Am J Physiol Renal Physiol 295: F556-F567, 2008. First published May 14, 2008; doi:10.1152/ajprenal.00340.2007 [Abstract] [Full Text] [PDF]  

Aurélie Edwards and Thomas L. Pallone

Mechanisms underlying angiotensin II-induced calcium oscillations
Am J Physiol Renal Physiol 295: F568-F584, 2008. First published June 18, 2008; doi:10.1152/ajprenal.00107.2008 [Abstract] [Full Text] [PDF]  

Xin Su, Erin S. R. Lashinger, Lisa A. Leon, Bryan E. Hoffman, J. Paul Hieble, Scott D. Gardner, Harvey E. Fries, Richard M. Edwards, Jun Li, and Nicholas J. Laping

An excitatory role for peripheral EP₃ receptors in bladder afferent function
Am J Physiol Renal Physiol 295: F585-F594, 2008. First published June 18, 2008; doi:10.1152/ajprenal.90273.2008 [Abstract] [Full Text] [PDF]  

Dong-Sub Jung, Jin Ji Li, Seung-Jae Kwak, Sun Ha Lee, Jehyun Park, Young Soo Song, Tae-Hyun Yoo, Seung Hyeok Han, Jung Eun Lee, Dong Ki Kim, Sung Jin Moon, Yu Seun Kim, Dae Suk Han, and Shin-Wook Kang

FR167653 inhibits fibronectin expression and apoptosis in diabetic glomeruli and in high-glucose-stimulated mesangial cells
Am J Physiol Renal Physiol 295: F595-F604, 2008. First published June 4, 2008; doi:10.1152/ajprenal.00624.2007 [Abstract] [Full Text] [PDF]  

Hang Yuan, Linda Lanting, Zhong-Gao Xu, Shu-Lian Li, Piotr Swiderski, Sumanth Putta, Mahesh Jonnalagadda, Mitsuo Kato, and Rama Natarajan

Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes
Am J Physiol Renal Physiol 295: F605-F617, 2008. First published June 18, 2008; doi:10.1152/ajprenal.90268.2008 [Abstract] [Full Text] [PDF]  

CALL FOR PAPERS:

Tiffany L. Thai and William J. Arendshorst

ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ET_A and ET_B receptor-induced renal vasoconstriction in vivo
Am J Physiol Renal Physiol 295: F360-F368, 2008. First published June 4, 2008; doi:10.1152/ajprenal.00512.2007 [Abstract] [Full Text] [PDF]  

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