EDITORIAL:

Thomas R. Kleyman and Gerardo Gamba

Editor's Note
Am J Physiol Renal Physiol 297: F837-F837, 2009. First published August 19, 2009; doi:10.1152/ajprenal.00454.2009 [Full Text] [PDF]  

EDITORIAL FOCUS:

Pablo A. Ortiz

Toll-like receptor 4 (TLR-4) regulates renal ion transport
Am J Physiol Renal Physiol 297: F864-F865, 2009. First published August 12, 2009; doi:10.1152/ajprenal.00437.2009 [Full Text] [PDF]  

David W. Good, Thampi George, and Bruns A. Watts, III

Lipopolysaccharide directly alters renal tubule transport through distinct TLR4-dependent pathways in basolateral and apical membranes
Am J Physiol Renal Physiol 297: F866-F874, 2009. First published July 22, 2009; doi:10.1152/ajprenal.00335.2009 [Abstract] [Full Text] [PDF]  

ARTICLES:

Kazuyoshi Inoue, Komal Sodhi, Nitin Puri, Katherine H. Gotlinger, Jiang Cao, Rita Rezzani, John R. Falck, Nader G. Abraham, and Michal Laniado-Schwartzman

Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE
Am J Physiol Renal Physiol 297: F875-F884, 2009. First published August 12, 2009; doi:10.1152/ajprenal.00364.2009 [Abstract] [Full Text] [PDF]  

Sang Won Park, Sean W. C. Chen, Mihwa Kim, Vivette D. D'Agati, and H. Thomas Lee

Human heat shock protein 27-overexpressing mice are protected against acute kidney injury after hepatic ischemia and reperfusion
Am J Physiol Renal Physiol 297: F885-F894, 2009. First published August 5, 2009; doi:10.1152/ajprenal.00317.2009 [Abstract] [Full Text] [PDF]  

Won Suk An, Hyun Ju Kim, Kyu-Hyang Cho, and Nosratola D. Vaziri

Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney
Am J Physiol Renal Physiol 297: F895-F903, 2009. First published August 5, 2009; doi:10.1152/ajprenal.00217.2009 [Abstract] [Full Text] [PDF]  

Wen Liu, Yuan Wei, Peng Sun, Wen-Hui Wang, Thomas R. Kleyman, and Lisa M. Satlin

Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C
Am J Physiol Renal Physiol 297: F904-F915, 2009. First published August 5, 2009; doi:10.1152/ajprenal.90685.2008 [Abstract] [Full Text] [PDF]  

Cristianne da Silva Alexandre, Ana Carolina de Bragança, Maria Heloísa Massola Shimizu, Talita Rojas Sanches, Maria Angela Zanella Fortes, Ricardo Rodrigues Giorgi, Lúcia Andrade, and Antonio Carlos Seguro

Rosiglitazone prevents sirolimus-induced hypomagnesemia, hypokalemia, and downregulation of NKCC2 protein expression
Am J Physiol Renal Physiol 297: F916-F922, 2009. First published August 5, 2009; doi:10.1152/ajprenal.90256.2008 [Abstract] [Full Text] [PDF]  

K. J. Kelly, James L. Burford, and Jesus H. Dominguez

Postischemic inflammatory syndrome: a critical mechanism of progression in diabetic nephropathy
Am J Physiol Renal Physiol 297: F923-F931, 2009. First published August 5, 2009; doi:10.1152/ajprenal.00205.2009 [Abstract] [Full Text] [PDF]  

Victoria Ramírez, Joyce Trujillo, Rafael Valdes, Norma Uribe, Cristino Cruz, Gerardo Gamba, and Norma A. Bobadilla

Adrenalectomy prevents renal ischemia-reperfusion injury
Am J Physiol Renal Physiol 297: F932-F942, 2009. First published August 5, 2009; doi:10.1152/ajprenal.00252.2009 [Abstract] [Full Text] [PDF]  

Farid Boubred, Laurent Daniel, Christophe Buffat, Jean-Marc Feuerstein, Michel Tsimaratos, Charles Oliver, Françoise Dignat-George, Martine Lelièvre-Pégorier, and Umberto Simeoni

Early postnatal overfeeding induces early chronic renal dysfunction in adult male rats
Am J Physiol Renal Physiol 297: F943-F951, 2009. First published August 5, 2009; doi:10.1152/ajprenal.90704.2008 [Abstract] [Full Text] [PDF]  

Yu Jin Jung, Duk Hoon Kim, Ae Sin Lee, Sik Lee, Kyung Pyo Kang, Sang Yong Lee, Kyu Yun Jang, Mi Jeong Sung, Sung Kwang Park, and Won Kim

Peritubular capillary preservation with COMP-angiopoietin-1 decreases ischemia-reperfusion-induced acute kidney injury
Am J Physiol Renal Physiol 297: F952-F960, 2009. First published August 5, 2009; doi:10.1152/ajprenal.00064.2009 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Richard A. Zager, Ali C. M. Johnson, and Steve Lund

Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury
Am J Physiol Renal Physiol 297: F961-F970, 2009. First published August 5, 2009; doi:10.1152/ajprenal.00381.2009 [Abstract] [Full Text] [PDF]  

Andrey V. Cybulsky, Tomoko Takano, Julie Guillemette, Joan Papillon, Rildo A. Volpini, and John A. Di Battista

The Ste20-like kinase SLK promotes p53 transactivation and apoptosis
Am J Physiol Renal Physiol 297: F971-F980, 2009. First published July 29, 2009; doi:10.1152/ajprenal.00294.2009 [Abstract] [Full Text] [PDF] [Corrigendum]  

Sabas I. Gomez, Lizette Warner, John A. Haas, Rodney J. Bolterman, Stephen C. Textor, Lilach O. Lerman, and Juan Carlos Romero

Increased hypoxia and reduced renal tubular response to furosemide detected by BOLD magnetic resonance imaging in swine renovascular hypertension
Am J Physiol Renal Physiol 297: F981-F986, 2009. First published July 29, 2009; doi:10.1152/ajprenal.90757.2008 [Abstract] [Full Text] [PDF]  

Andrey V. Cybulsky, Tomoko Takano, Joan Papillon, Krikor Bijian, Julie Guillemette, and Chris R. J. Kennedy

Glomerular epithelial cell injury associated with mutant -actinin-4
Am J Physiol Renal Physiol 297: F987-F995, 2009. First published July 29, 2009; doi:10.1152/ajprenal.00055.2009 [Abstract] [Full Text] [PDF]  

Maoyin Pang, Jagan Kothapally, Haiping Mao, Evelyn Tolbert, Murugavel Ponnusamy, Y. Eugene Chin, and Shougang Zhuang

Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy
Am J Physiol Renal Physiol 297: F996-F1005, 2009. First published July 29, 2009; doi:10.1152/ajprenal.00282.2009 [Abstract] [Full Text] [PDF]  

Hiroko Sonoda, Naoko Yokota-Ikeda, Sayaka Oshikawa, Yosuke Kanno, Kazuya Yoshinaga, Kazuyuki Uchida, Yuuji Ueda, Kouichi Kimiya, Shigehiro Uezono, Akira Ueda, Katsuaki Ito, and Masahiro Ikeda

Decreased abundance of urinary exosomal aquaporin-1 in renal ischemia-reperfusion injury
Am J Physiol Renal Physiol 297: F1006-F1016, 2009. First published July 29, 2009; doi:10.1152/ajprenal.00200.2009 [Abstract] [Full Text] [PDF]  

Kristin J. Bergsland, Fredric L. Coe, Daniel L. Gillen, and Elaine M. Worcester

A test of the hypothesis that the collecting duct calcium-sensing receptor limits rise of urine calcium molarity in hypercalciuric calcium kidney stone formers
Am J Physiol Renal Physiol 297: F1017-F1023, 2009. First published July 29, 2009; doi:10.1152/ajprenal.00223.2009 [Abstract] [Full Text] [PDF]  

Minoru Miyazato, Yasuhiro Kaiho, Izumi Kamo, Takeya Kitta, Michael B. Chancellor, Kimio Sugaya, Yoichi Arai, William C. de Groat, and Naoki Yoshimura

Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats
Am J Physiol Renal Physiol 297: F1024-F1031, 2009. First published July 29, 2009; doi:10.1152/ajprenal.00297.2009 [Abstract] [Full Text] [PDF]  

Wei Wang, Shweta Bansal, Sandor Falk, Danica Ljubanovic, and Robert Schrier

Ghrelin protects mice against endotoxemia-induced acute kidney injury
Am J Physiol Renal Physiol 297: F1032-F1037, 2009. First published July 22, 2009; doi:10.1152/ajprenal.00044.2009 [Abstract] [Full Text] [PDF]  

Bopaiah P. Cheppudira, Beatrice M. Girard, Susan E. Malley, Abbey Dattilio, Kristin C. Schutz, Victor May, and Margaret A. Vizzard

Involvement of JAK-STAT signaling/function after cyclophosphamide-induced bladder inflammation in female rats
Am J Physiol Renal Physiol 297: F1038-F1044, 2009. First published July 22, 2009; doi:10.1152/ajprenal.00110.2009 [Abstract] [Full Text] [PDF]  

Yufeng Huang, Wayne A. Border, Daniel A. Lawrence, and Nancy A. Noble

Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis
Am J Physiol Renal Physiol 297: F1045-F1054, 2009. First published July 22, 2009; doi:10.1152/ajprenal.00024.2009 [Abstract] [Full Text] [PDF]  

Jingfei Cheng, Wei Zhou, Gina M. Warner, Bruce E. Knudsen, Vesna D. Garovic, Catherine E. Gray, Lilach O. Lerman, Jeffrey L. Platt, J. Carlos Romero, Stephen C. Textor, Karl A. Nath, and Joseph P. Grande

Temporal analysis of signaling pathways activated in a murine model of two-kidney, one-clip hypertension
Am J Physiol Renal Physiol 297: F1055-F1068, 2009. First published July 22, 2009; doi:10.1152/ajprenal.90439.2008 [Abstract] [Full Text] [PDF]  

Young Hee Kim, Truyen D. Pham, Wencui Zheng, Seongun Hong, Christine Baylis, Vladimir Pech, William H. Beierwaltes, Donna B. Farley, Lewis E. Braverman, Jill W. Verlander, and Susan M. Wall

Role of pendrin in iodide balance: going with the flow
Am J Physiol Renal Physiol 297: F1069-F1079, 2009. First published July 15, 2009; doi:10.1152/ajprenal.90581.2008 [Abstract] [Full Text] [PDF]  

Qing-Hua Hu, Chuang Wang, Jian-Mei Li, Dong-Mei Zhang, and Ling-Dong Kong

Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement
Am J Physiol Renal Physiol 297: F1080-F1091, 2009. First published July 15, 2009; doi:10.1152/ajprenal.90767.2008 [Abstract] [Full Text] [PDF]  

William H. Fissell, Christina L. Hofmann, Nicholas Ferrell, Lisa Schnell, Anna Dubnisheva, Andrew L. Zydney, Peter D. Yurchenco, and Shuvo Roy

Solute partitioning and filtration by extracellular matrices
Am J Physiol Renal Physiol 297: F1092-F1100, 2009. First published July 8, 2009; doi:10.1152/ajprenal.00162.2009 [Abstract] [Full Text] [PDF]  

Andy Chang, Stephan Butler, Joanna Sliwoski, Rita Valentino, Douglas Canning, and Stephen Zderic

Social stress in mice induces voiding dysfunction and bladder wall remodeling
Am J Physiol Renal Physiol 297: F1101-F1108, 2009. First published July 8, 2009; doi:10.1152/ajprenal.90749.2008 [Abstract] [Full Text] [PDF]  

Hsi-Hsien Chen, Tzen-Wen Chen, and Heng Lin

Prostacyclin-induced peroxisome proliferator-activated receptor- translocation attenuates NF-B and TNF- activation after renal ischemia-reperfusion injury
Am J Physiol Renal Physiol 297: F1109-F1118, 2009. First published July 29, 2009; doi:10.1152/ajprenal.00057.2009 [Abstract] [Full Text] [PDF]  

John E. Speich, Atheer M. Almasri, Hersch Bhatia, Adam P. Klausner, and Paul H. Ratz

Adaptation of the length-active tension relationship in rabbit detrusor
Am J Physiol Renal Physiol 297: F1119-F1128, 2009. First published August 12, 2009; doi:10.1152/ajprenal.00298.2009 [Abstract] [Full Text] [PDF]  

INNOVATIVE METHODOLOGY:

Kambiz Kalantarinia, J. Todd Belcik, James T. Patrie, and Kevin Wei

Real-time measurement of renal blood flow in healthy subjects using contrast-enhanced ultrasound
Am J Physiol Renal Physiol 297: F1129-F1134, 2009. First published July 22, 2009; doi:10.1152/ajprenal.00172.2009 [Abstract] [Full Text] [PDF]  

CORRIGENDA:

Corrigendum
Am J Physiol Renal Physiol 297: F1135-F1135, 2009; doi:10.1152/ajprenal.zh2-5691-corr.2009 [Full Text] [PDF]  

REVIEW:

Gerardo Gamba

The thiazide-sensitive Na⁺-Cl^– cotransporter: molecular biology, functional properties, and regulation by WNKs
Am J Physiol Renal Physiol 297: F838-F848, 2009. First published May 27, 2009; doi:10.1152/ajprenal.00159.2009 [Abstract] [Full Text] [PDF] [Supplemental Animations]  

Paul A. Welling and Kevin Ho

A comprehensive guide to the ROMK potassium channel: form and function in health and disease
Am J Physiol Renal Physiol 297: F849-F863, 2009. First published May 20, 2009; doi:10.1152/ajprenal.00181.2009 [Abstract] [Full Text] [PDF]  

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