Table 1.

Body and kidney weights and blood data in AS+/+, AS+/−, and AS−/− mice on a normal-salt diet

AS+/+AS+/−AS−/−
Body wt, g25.1±0.7 (10)24.6±1.1 (10)20.3±1.1b,c (10)
Kidney weight, g0.35±0.03 (10)0.32±0.02 (10)0.25±0.02a (10)
Kidney weight, g/20 g body wt0.27±0.01 (10)0.26±0.01 (10)0.25±0.02 (10)
Food intake, g/20 g body wt3.01±0.14 (14)3.43±0.12a (15)3.90±0.19c,d (16)
Blood chemistry
    Hematocrit, %53.0±2.2 (10)51.5±3.8 (10)54.9±1.9 (10)
    Protein, g/dl5.8±0.1 (16)6.0±0.1 (15)6.4±0.2b,c (15)*
    Glucose, mg/dl212±9 (15)214±12 (9)223±8 (18)
    Aldosterone, pg/ml604±130 (7)515±70 (6)ND
    Corticosterone, ng/ml51±11 (11)67±16 (7)79±6a (11)
  • Values are means ± SE; no. of animals is in parentheses. AS, aldosterone synthase; ND, not detectable.

  • a P < 0.05 vs. AS+/+ mice.

  • b P < 0.01 vs. AS+/+ mice.

  • c P < 0.05 vs. AS+/− mice.

  • d P < 0.001 vs. AS+/+ mice.