Table 2.

Plasma electrolytes, urinary excretion of electrolytes, and creatinine clearance in AS+/+, AS+/−, and AS−/− mice

AS+/+AS+/−AS−/−
Plasma
    Na+, mM136.8±1.5 (12)135.7±1.2 (11)137.2±1.29 (9)
    K+, mM5.9±0.1 (18)6.2±0.2 (24)6.7±0.2b,c (20)
    Ca2+, mg/dl10.1±0.2 (11)9.8±0.2 (9)10.9±0.3a,d (10)
    Mg2+, mg/dl2.0±0.01 (14)1.9±0.1 (13)2.2±0.1a,d (10)
    Cl, mM126.9±0.8 (20)126.8±1.0 (19)123.6±1.2a,c (16)
    Phosphorus, mg/dl5.5±0.2 (6)6.2±0.5 (5)5.3±0.3 (6)
    Lactate, mM6.3±0.3 (6)6.2±0.6 (5)6.5±0.6 (6)
    pH7.43±0.04 (6)7.31±0.01a (6)
    HCO3, mM24.1±0.6 (6)18.9±1.1b (4)
Urine
    UNaV, μmol/dl253±12 (11)285±12 (11)278±11 (13)
    UKV, μmol/dl386±17 (10)428±16 (11)387±15 (13)
    KetonesND (6)ND (6)ND (6)
    Cr clearence, ml/min0.38±0.09 (8)0.51±0.12 (7)0.49±0.07 (9)
  • Values are means ± SE; no. of animals in parentheses. Cr, creatinine; UNaV, urinary sodium excretion; UKV, urinary potassium excretion.

  • a P < 0.05 vs. AS+/+ mice.

  • b P < 0.01 vs. AS+/+ mice.

  • c P < 0.05 vs. AS+/− mice.

  • d P < 0.01 vs. AS+/− mice.