Table 3.

mRNA levels in the kidney of AS+/+, AS+/−, and AS−/− mice on normal salt diet

AS+/+AS+/−AS−/−
Renin100±7 (19)157±36 (18)1,171±109d,g (20)
MR100±7 (19)95±6 (18)83±7 (20)
GR100±8 (19)97±10 (18)66±5b,e (20)
11β-HSD1100±7 (19)98±8 (18)82±12 (20)
11β-HSD2100±8 (19)120±12 (18)145±6a (20)
Sgk100±8 (19)114±16 (18)97±10 (20)
α-ENaC100±9 (19)99±4 (17)111±8 (20)
β-ENaC100±6 (19)108±11 (18)113±9 (20)
γ-ENaC100±7 (19)93±8 (18)117±8 (20)
NCC100±5 (19)91±8 (18)76±5c (20)
NKCC2100±7 (20)105±7 (17)104±6 (20)
NHE3100±6 (20)98±7 (17)95±7 (20)
ROMK (cortex)100±15 (9)82±13 (9)59±10a (8)
COX-1 (cortex)100±16 (9)102±12 (9)105±16 (9)
COX-2 (cortex)100±15 (9)122±19 (9)539±91c,f (9)
  • Values (wild type as 100%) are means ± SE; no. in parentheses is no. of animals. MR, mineralocorticoid receptor; GR, glucocorticoid receptor; 11β-HSD, 11β-hydroxysteroid dehydrogenase; Sgk, serum- and glucocorticoid-inducible kinase; ENaC, epithelial Na+ channel; NCC, Na+-Cl cotransporter; NKCC, Na+-K+-2Cl cotransporter; NHE, Na+/H+ exchanger; COX, cyclooxygenase.

  • a P < 0.05 vs. AS+/+ mice.

  • b P < 0.01 vs. AS+/+ mice.

  • c P < 0.001 vs. AS+/+ mice.

  • d P < 0.0001 vs. AS+/+ mice.

  • e P < 0.05 vs. AS+/− mice.

  • f P < 0.001 vs. AS+/− mice.

  • g P < 0.0001 vs. AS+/− mice.