Table 1.

Threshold and peak micturition and filling pressures during conscious cystometry for control and 48 h CYP-treated rats both pre- and post-AMD-3100 treatment

Threshold PressurePeak Micturition PressureFilling Pressure
Control
    Pre-AMD14.2 + 0.751.7 + 1.610.6 + 0.6
    Post-AMD14.0 + 0.947.7 + 2.09.7 + 0.6
48 h CYP
    Pre-AMD24.3 + 1.1*65.4 + 3.2*23.1 + 1.1*
    Post-AMD23.6 + 1.274.4 + 5.122.5 + 1.2
  • Values presented are means ± SE; n = 4–6 rats in each group. Units are cmH2O. CYP, cyclophosphomide; AMD, AMD-3100. No pressure changes were observed within experimental groups (i.e., control pre-AMD vs. post-AMD or CYP pre-AMD vs. post-AMD) following AMD-3100 (5 μM) instillation; however, CYP treatment (48 h) significantly (

  • * P ≤ 0.05) increased threshold and peak micturition and filling pressures when compared with control rats.