Table 1.

Body mass and renal function measurements

SHAMSEDARGRUNRUN+ARG
Body mass, g432 ± 9376 ± 13*376 ± 18*402 ± 9388 ± 17
Urine protein excretion, mg·24 h−1·100 g−1 BM
Baseline6.2 ± 0.75.3 ± 0.85.8 ± 0.56.2 ± 0.77.2 ± 1.5
Week 44.5 ± 0.842.4 ± 5.850.3 ± 12.235.7 ± 4.541.4 ± 7.0
Week 86.0 ± 0.851.7 ± 6.148.4 ± 9.453.5 ± 6.765.5 ± 7.1
Creatinine clearance, ml·min−1·100 g BM−11.2 ± 0.420.34 ± 0.09*0.26 ± 0.11*0.20 ± 0.090.22 ± 0.07
BUN, mg/dl25.5 ± 0.972.15 ± 2.5*71.5 ± 2.1*69.3 ± 2.6*68.3 ± 4.5*
  • Values are mean ± SE.

  • BM, body mass; BUN blood urea nitrogen; SED, sedentary rats; RUN, wheel-running rats; ARG, l-arginine-treated rats.

  • * P < 0.05 vs. SHAM.

  • P < 0.001 vs. SHAM; n = 5–8/group.